INT26678

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 3.45
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
Posterior 1
nucleus 1
heart 1
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 1 99.12 Very High Very High Very High
Glutamate 1 97.94 Very High Very High Very High
depression 3 97.20 Very High Very High Very High
tolerance 12 62.96 Quite High
fibrosis 2 56.32 Quite High
abdominal pain 6 9.08 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 6 99.60 Very High Very High Very High
Depression 3 97.20 Very High Very High Very High
Targeted Disruption 128 96.48 Very High Very High Very High
Arrhythmias 2 Under Development 26 96.36 Very High Very High Very High
Muscle Disease 9 95.56 Very High Very High Very High
Hypopituitarism 78 95.04 Very High Very High Very High
Heart Disease 8 91.28 High High
Toxicity 66 89.96 High High
Disease 115 87.24 High High
Congenital Anomalies 41 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the one hand, the activity of the ribonuclease downregulates the mutant DMPK transcript, which removes a toxic RNA from the cell and may contribute to the reduction of DMPK expression levels.
Negative_regulation (downregulates) of DMPK
1) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
On the one hand, the activity of the ribonuclease downregulates the mutant DMPK transcript, which removes a toxic RNA from the cell and may contribute to the reduction of DMPK expression levels.
Negative_regulation (reduction) of DMPK
2) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Together this indicates that it is not loss of DMPK function that causes the phenotypes of DM1, but instead an RNA gain of function.
Negative_regulation (loss) of DMPK
3) Confidence 0.43 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 1.23 Pain Relevance 0
Three non-exclusive molecular defects hypothesized to contribute to DM1 pathology are (i) decreased DMPK levels resulting from aberrant nuclear accumulation of the mutant DMPK RNA [14], [15] (ii) decreased SIX5 levels occurring as a consequence of chromatin condensation that occurs in the vicinity of the expanded CTG tract [16]–[18] and (iii) intrinsic toxicity of the expanded CUG tracts [19].
Negative_regulation (decreased) of DMPK associated with toxicity
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.84 Pain Relevance 0.03
Other studies demonstrated that the mutant DMPK transcripts are completely blocked in nuclei [37,38].
Negative_regulation (blocked) of DMPK
5) Confidence 0.37 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
These observations and the detection of mutant DMPK transcripts retained in the nucleus of DM fibroblasts and muscle biopsies supported the hypothesis of loss of DMPK function (DMPK haploinsufficiency) as the mechanism of pathogenesis of DM1 [19, 20].
Negative_regulation (loss) of DMPK in nucleus
6) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Initial reports using antisera and semiquantitative reverse transcriptase-polymerase chain reaction reported decreased levels of both DMPK mRNA and protein in adult forms of DM1, suggesting that large CTG repeat expansions altered DMPK mRNA synthesis and processing [15-18].
Negative_regulation (decreased) of DMPK
7) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.05 Pain Relevance 0
Recently, transcripts containing long hairpin structures of CUG repeats have been shown to be a Dicer ribonuclease target and Dicer-induced downregulation of the mutant DMPK transcripts triggers silencing effects on RNAs containing long complementary repeats.
Negative_regulation (downregulation) of DMPK
8) Confidence 0.34 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.07 Pain Relevance 0
Such reduction of the mutant DMPK mRNA export could be because of diminished capacity of the modification enzymes to process the mutant DMPK mRNA.
Negative_regulation (reduction) of mutant DMPK mRNA
9) Confidence 0.33 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
As reduction in Dmpk and Six5 levels does not completely recapitulate the severity of DM1 cardiac pathology, these data suggest that toxic effects associated with the expression of CUG repeats play a prominent role in the etiology of DM1 heart disease.
Negative_regulation (reduction) of Dmpk in heart associated with heart disease
10) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.85 Pain Relevance 0
Posterior studies confirmed that DMPK transcription was altered in patients and that there was no correlation between CTG repeat length and DMPK protein reduction [23-25].
Negative_regulation (reduction) of DMPK in Posterior
11) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.31 Pain Relevance 0.03
When the short train stimulation was delivered during expiration, inspiration would be initiated prematurely. (3) Microinjection of L-glutamate (0.5 M, 0.5-2 microliters) into the dmNF also increased inspiratory duration and amplitude. (4) Focal block of the dmNF by microinjection of lidocaine (2%, 1-2 microliters) produced strong depression or complete cessation of inspiration.
Negative_regulation (block) of dmNF associated with glutamate, depression and lidocaine
12) Confidence 0.24 Published 1989 Journal Respir Physiol Section Abstract Doc Link 2566192 Disease Relevance 0.10 Pain Relevance 0.20

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