INT266786

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.87
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ASAH1) lipid metabolic process (ASAH1)
Anatomy Link Frequency
peritoneal macrophages 1
ASAH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 336 99.98 Very High Very High Very High
peripheral neuropathy 2 87.92 High High
Spinal cord 4 77.60 Quite High
Pain 34 40.16 Quite Low
Inflammation 89 38.16 Quite Low
cytokine 54 5.00 Very Low Very Low Very Low
substance P 42 5.00 Very Low Very Low Very Low
Nerve growth factor 32 5.00 Very Low Very Low Very Low
metalloproteinase 26 5.00 Very Low Very Low Very Low
Catecholamine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 38 100.00 Very High Very High Very High
Endometriosis 448 99.98 Very High Very High Very High
Motor Neuron Diseases 88 99.66 Very High Very High Very High
Disease 55 98.28 Very High Very High Very High
Megaloblastic Anemia 1 91.36 High High
Glossitis 1 89.60 High High
Dementia 1 88.72 High High
Peripheral Neuropathy 3 87.92 High High
Spinal Cord Diseases 5 85.84 High High
Adhesions 26 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there are interesting correlations between PHP and SHP, MND/ALS with aberrant calcium, vitamin D, and PTH metabolism, most of the literature does not indicate a conclusive relationship between ALS and PHP/SHP and treatment of PHP/SHP does not lead to improvement of MND.


PHP Binding (treatment) of associated with hypercalcemia and motor neuron diseases
1) Confidence 0.11 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 2.39 Pain Relevance 0.08
Sharpe-Timms et al. [83] showed that peritoneal macrophages from women with endometriosis bind more pHp in vivo than those from women without the disease, although the concentration of pHp is similar in both groups.
pHp Binding (bind) of in peritoneal macrophages associated with endometriosis and disease
2) Confidence 0.02 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.80 Pain Relevance 0.18
Increased interaction of pHp with different lectins might be due to variations in the ratios of ?
pHp Spec (might) Binding (interaction) of
3) Confidence 0.02 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.68 Pain Relevance 0.18

General Comments

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