INT266811

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.06
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRH1, HTR2C) nucleus (HRH1, HTR2C) cytoplasm (HRH1, HTR2C)
signal transducer activity (HRH1, HTR2C) nucleolus (HRH1)
HRH1 (Homo sapiens)
HTR2C (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 222 99.06 Very High Very High Very High
Serotonin 18 86.48 High High
depression 18 74.16 Quite High
Nortriptyline 12 72.28 Quite High
fluoxetine 15 62.12 Quite High
Endep 6 58.08 Quite High
antagonist 3 21.64 Low Low
agonist 3 21.04 Low Low
iatrogenic 3 6.32 Low Low
Disease Link Frequency Relevance Heat
Hypoglycemia 129 96.08 Very High Very High Very High
Body Weight 3 89.32 High High
Hyperglycemia 6 83.92 Quite High
Diabetes Mellitus 81 80.72 Quite High
Depression 21 74.16 Quite High
Appetite Loss 6 71.20 Quite High
Stress 3 69.28 Quite High
Stroke 3 68.00 Quite High
Weight Gain 6 67.28 Quite High
Myocardial Infarction 3 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the association between hyperglycaemia and use of antidepressants was most pronounced for antidepressants from cluster 2 and cluster 3 with corresponding binding properties for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
H1 receptor Binding (receptor) of 5-HT2c associated with antidepressant
1) Confidence 0.23 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.71 Pain Relevance 0.33
The association between antidepressant use and hyperglycaemia was most pronounced for antidepressants with high affinity for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
H1 receptor Binding (receptor) of 5-HT2c associated with antidepressant
2) Confidence 0.23 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.43 Pain Relevance 0.47
The association of hyperglycaemia was most pronounced for antidepressants with corresponding binding properties for the 5-HT2c receptor, H1 receptor and NE reuptake transporter.
H1 receptor Binding (receptor) of 5-HT2c associated with antidepressant
3) Confidence 0.23 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.92 Pain Relevance 0.60

General Comments

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