INT266819

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Grxcr1) molecular_function (Grxcr1)
Anatomy Link Frequency
renal tubule 2
osteoblast 2
Grxcr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 5 99.84 Very High Very High Very High
Rickets 73 94.48 High High
Hypophosphatemia 11 90.32 High High
Calcification 6 89.40 High High
Death 5 81.16 Quite High
Kidney Stones 5 73.48 Quite High
Anaemia 14 64.76 Quite High
Embryonic Lethality 8 54.52 Quite High
Disease 10 51.60 Quite High
Hypercalcemia 3 28.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated concentrations of FGF23 internalise and reduce the NaPi-IIa and c cotransporters in the proximal renal tubule, reducing Pi reabsorption and suppressing 1 alpha-hydroxylase activity, thus, reducing 1,25-(OH)2D and serum Pi concentrations (Fig. 2) [11].
Regulation (reducing) of Localization (reabsorption) of Pi in renal tubule
1) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.80 Pain Relevance 0
PiT1, but not PiT2, mRNA and Na+-Pi transport were found to be regulated in osteoblast-like and chondrogenic cells by various factors, mainly Pi, IGF-1, BMP2 and TGF-?
Regulation (regulated) of Localization (transport) of Pi in osteoblast associated with osteoporosis
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.48 Pain Relevance 0

General Comments

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