INT266823

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Grxcr1) molecular_function (Grxcr1)
Anatomy Link Frequency
thyroid 1
osteoblast 1
growth plate 1
Grxcr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 1 52.16 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 5 98.86 Very High Very High Very High
Rickets 146 91.92 High High
Targeted Disruption 70 86.76 High High
Hypophosphatemia 22 83.72 Quite High
Heart Rate Under Development 3 78.32 Quite High
Kidney Stones 10 66.88 Quite High
Calcification 6 61.84 Quite High
Osteoarthritis 1 52.16 Quite High
Disease 20 45.00 Quite Low
Hypercalcemia 6 43.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CrP/Pi ratio is a parameter well suited to describing the cellular energy state in tissues containing creatine kinase, since the changes in the CrP and Pi concentrations are usually reciprocal.
Regulation (changes) of Pi
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680037 Disease Relevance 0.44 Pain Relevance 0
The resultant low serum Pi concentrations may be directly responsible for the rachitic changes at the growth plate, but it is likely that FGF23 has a direct effect on the mineralisation of newly formed osteoid at the trabecular bone surface, resulting in the features of osteomalacia [17].
Spec (may) Regulation (responsible) of Pi in growth plate associated with rickets
2) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.67 Pain Relevance 0
A number of factors influence the renal tubular reabsorption of Pi, such as dietary phosphorus content, and parathyroid hormone (PTH), growth hormone (insulin-like growth factor 1) and thyroid hormone concentrations, although these latter two hormones probably do not play a major role in the short-term control of serum Pi concentrations, but, rather, determine long-term concentrations.
Regulation (control) of Pi in thyroid
3) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0 Pain Relevance 0
In osteoblast-like cells, PiT1, but not PiT2, mRNA expression and Na+-Pi cotransport are regulated by various factors such as Pi [10], epinephrine [11], insulin-like growth factor 1 (IGF-1) [12], [13] and bone morphogenic protein 2 (BMP2) [14].
Regulation (regulated) of Pi in osteoblast associated with osteoporosis
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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