INT266828

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.63
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23) extracellular region (Fgf23)
Fgf23 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 2 83.28 Quite High
Bile 32 12.08 Low Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 34 99.60 Very High Very High Very High
Metabolic Disorder 16 98.84 Very High Very High Very High
Bone Cancer 2 98.52 Very High Very High Very High
Rickets 182 98.28 Very High Very High Very High
Calcification 12 96.48 Very High Very High Very High
Targeted Disruption 74 94.00 High High
Hypophosphatemia 30 92.68 High High
Syndrome 10 90.12 High High
Disease 32 88.24 High High
Familial Hypophosphatemia 6 80.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Removal of the tumour results in a rapid decline in FGF23 concentrations and a restoration of normal biochemistry and healing of the osteomalacia/rickets.
Negative_regulation (decline) of FGF23 associated with rickets and cancer
1) Confidence 0.42 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.90 Pain Relevance 0.04
However, it is unclear whether the bone disease and, in particular, the peri-osteocytic lesions are a direct or indirect effect of FGF23.
Negative_regulation (effect) of FGF23 associated with bone cancer
2) Confidence 0.42 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.16 Pain Relevance 0
Reduced Fgf23 signaling also causes human metabolic disorders.
Negative_regulation (Reduced) of Fgf23 associated with metabolic disorder
3) Confidence 0.38 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.44 Pain Relevance 0
The loss-of-function mutation of Galnt3 impairs secretion of intact Fgf23, leading to decreased serum Fgf23 levels and hyperphosphatemia (Ichikawa et al. 2009).
Negative_regulation (decreased) of Fgf23
4) Confidence 0.34 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.14 Pain Relevance 0

General Comments

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