INT266832

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.91
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Grxcr1) molecular_function (Grxcr1)
Anatomy Link Frequency
plasma 1
cochlea 1
Grxcr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 68.80 Quite High
ketamine 6 27.28 Quite Low
Somatostatin 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 18 100.00 Very High Very High Very High
Rickets 438 99.90 Very High Very High Very High
Disease 60 99.34 Very High Very High Very High
Nephrotoxicity 6 97.68 Very High Very High Very High
Pressure And Volume Under Development 4 96.56 Very High Very High Very High
Osteoporosis 15 96.24 Very High Very High Very High
Apoptosis 134 95.28 Very High Very High Very High
Calcification 18 95.20 Very High Very High Very High
Dent Disease 6 95.20 Very High Very High Very High
Cerebellooculorenal Syndrome 6 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI (+) was nuclear condensation featured by nuclear condensation with an increase in PI fluorescence staining.
Positive_regulation (increase) of PI
1) Confidence 0.12 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.45 Pain Relevance 0
The majority of dietary Pi is absorbed by passive concentration-dependent processes, but the active metabolite of vitamin D (1,25-dihydroxyvitamin D(1,25(OH)2D)) does increase the intestinal Pi absorption marginally.
Positive_regulation (increase) of Pi
2) Confidence 0.09 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.06 Pain Relevance 0
The number of FITC (+) PI (+) cells was higher than FITC (-) PI (+) in the apex, while the number of FITC (-) PI (+) increased toward the base of the cochlea and outran the number of FITC (+) PI (+) cells after the fifth region, corresponding to 26% of the whole length of the cochlea.


Positive_regulation (increased) of PI in cochlea
3) Confidence 0.08 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.25 Pain Relevance 0
Notably, a recent report shows that under physiological conditions, the Pi-transport activity of PiT1 is saturated [49], implying that only an increase in the capacity (i.e. enhanced expression of functional Pi transporters) can mediate an increase in Pi influx.
Positive_regulation (increase) of Pi
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.23 Pain Relevance 0
These findings raise concerns about the possible role of treatment (calcitriol) in stimulating FGF23 concentrations and, thus, increasing renal Pi loss, inducing a vicious cycle of increasing Pi supplements, increasing secondary hyperparathyroidism and further Pi loss.
Positive_regulation (increasing) of Pi associated with hypercalcemia
5) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.50 Pain Relevance 0.06
Numerous diseases are associated with rickets and increased renal Pi loss; however, it is the isolated phosphaturic entities that have attracted the most attention over the past decade, as the isolation of the genetic mutations responsible for their pathogenesis has resulted in a new understanding of the hormonal axis between bone mineralisation, renal Pi handling and vitamin D metabolism (TableĀ 2).


Positive_regulation (increased) of Pi associated with rickets and disease
6) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.49 Pain Relevance 0
These findings raise concerns about the possible role of treatment (calcitriol) in stimulating FGF23 concentrations and, thus, increasing renal Pi loss, inducing a vicious cycle of increasing Pi supplements, increasing secondary hyperparathyroidism and further Pi loss.
Positive_regulation (increasing) of Pi associated with hypercalcemia
7) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.61 Pain Relevance 0.07
These findings raise concerns about the possible role of treatment (calcitriol) in stimulating FGF23 concentrations and, thus, increasing renal Pi loss, inducing a vicious cycle of increasing Pi supplements, increasing secondary hyperparathyroidism and further Pi loss.
Positive_regulation (increasing) of Pi associated with hypercalcemia
8) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.57 Pain Relevance 0.06
Both PTH and 1,25-(OH)2D increase FGF23 production, which helps to reduce the Pi load induced by increased intestinal Pi absorption and bone resorption associated with elevated levels of the two former hormones.
Positive_regulation (induced) of Pi associated with hypercalcemia
9) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.50 Pain Relevance 0
Studies conducted in VSMCs have led to the proposal that an increase in Pi influx through the plasma membrane could lead to the to the transdifferentiation of VSMCs in osteoblast-like cells and calcification of the extracellular matrix under high extracellular Pi concentration [19].
Positive_regulation (increase) of Pi in plasma associated with calcification and osteoporosis
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.19 Pain Relevance 0
As such, PiT1 is often considered as a ubiquitous supplier of Pi for cellular needs regardless of the lack of experimental data.
Positive_regulation (supplier) of Pi
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2818845 Disease Relevance 0.06 Pain Relevance 0

General Comments

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