INT266839

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) transport (Slc34a1) extracellular space (Fgf23)
extracellular region (Fgf23) plasma membrane (Slc34a1)
Anatomy Link Frequency
renal tubule 1
Fgf23 (Mus musculus)
Slc34a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 73 98.20 Very High Very High Very High
Hypophosphatemia 11 94.04 High High
Kidney Stones 5 77.20 Quite High
Disease 10 55.32 Quite High
Syndrome 4 30.12 Quite Low
Nevus 1 29.36 Quite Low
Neurocutaneous Syndromes 1 28.60 Quite Low
Polyostotic Fibrous Dysplasia 2 27.08 Quite Low
Hypercalcemia 3 22.56 Low Low
Cancer 12 13.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated concentrations of FGF23 internalise and reduce the NaPi-IIa and c cotransporters in the proximal renal tubule, reducing Pi reabsorption and suppressing 1 alpha-hydroxylase activity, thus, reducing 1,25-(OH)2D and serum Pi concentrations (Fig. 2) [11].
FGF23 Negative_regulation (reduce) of NaPi-IIa in renal tubule
1) Confidence 0.21 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.88 Pain Relevance 0

General Comments

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