INT266875

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 37
Total Number 45
Disease Relevance 38.43
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Narfl) cellular_component (Narfl)
Anatomy Link Frequency
eyes 4
retina 3
optic nerve 3
fundus 3
retinal layers 3
Narfl (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 819 99.96 Very High Very High Very High
imagery 93 99.30 Very High Very High Very High
anesthesia 264 95.44 Very High Very High Very High
cytokine 45 93.36 High High
Kinase C 390 87.60 High High
Arthritis 9 73.32 Quite High
rheumatoid arthritis 9 72.48 Quite High
Infliximab 9 64.24 Quite High
Adalimumab 9 63.76 Quite High
Etanercept 9 62.08 Quite High
Disease Link Frequency Relevance Heat
Ocular Hypertension 3663 100.00 Very High Very High Very High
Cv Unclassified Under Development 585 99.96 Very High Very High Very High
Injury 552 99.86 Very High Very High Very High
Optic Disorders 198 99.32 Very High Very High Very High
Glaucoma 441 98.80 Very High Very High Very High
Ganglion Cysts 363 98.60 Very High Very High Very High
Retina Disease 285 98.32 Very High Very High Very High
Death 342 98.00 Very High Very High Very High
Disease 144 96.40 Very High Very High Very High
Pallor 3 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, an important increase of the IOP was already evident and peaked at 24 h after lasering (Kruskal–Wallis test, p<0.0001); this was maintained for four days and returned gradually after the fifth day to the basal value, so that by one week after lasering, the IOP values in animals of different groups were comparable for both eyes (Kruskal–Wallis test, p=0.8191; Figure 1).


Positive_regulation (increase) of IOP in eyes associated with ocular hypertension
1) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.66 Pain Relevance 0
To avoid fluctuations due to the circadian rhythm of the mice [33] or to the elevated IOP itself [66], we tested IOP always around the same time, preferentially in the morning and immediately after deep anesthesia.
Positive_regulation (elevated) of IOP associated with anesthesia and ocular hypertension
2) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.81 Pain Relevance 0.27
Similar abrupt elevations of IOP have been observed for pigmented mice, in which the trabecular meshwork and the episcleral veins were photocoagulated with a laser [60].
Positive_regulation (elevations) of IOP in meshwork associated with ocular hypertension
3) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.40 Pain Relevance 0
This survival interval was chosen because it has been shown in rats that the largest number of RT97 immunopositive (RT97+) RGCs occurs between two and three weeks after injury, either by axotomy [74] or by elevated IOP [26].
Positive_regulation (elevated) of IOP associated with injury and ocular hypertension
4) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.20 Pain Relevance 0
Our electrophysiological analysis demonstrates that shortly after LP, there is an important reduction in the amplitude of the STR and the other two main components of the ERG, the a- and b-waves; these reductions are permanent throughout the period of study, indicating that elevation of IOP in albino mice results in damage not only to the RGC layer, but also to other retinal layers.
Positive_regulation (elevation) of IOP in retinal layers associated with ocular hypertension
5) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.58 Pain Relevance 0
To study the effect of IOP elevation on the ERG waves in albino mice, simultaneous ERG recordings were performed on the right and left eyes of each animal before surgery.
Positive_regulation (elevation) of IOP in eyes associated with ocular hypertension
6) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.59 Pain Relevance 0
In the present work, we have used one of the available experimental models of OHT-induced retinal damage [24,25] to study the mechanisms by which elevated IOP causes retinal damage in adult albino mice.
Positive_regulation (elevated) of IOP associated with ocular hypertension
7) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.57 Pain Relevance 0
The lasering methodology employed in the present study resulted in a rapid increase of IOP that was maintained for a short period of time.
Positive_regulation (increase) of IOP associated with ocular hypertension
8) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.45 Pain Relevance 0
Elevation of IOP, the primary risk factor for glaucoma, is also the most common approach to induce experimental models in which to study pathophysiology involved with glaucomatous optic neuropathy.
Positive_regulation (Elevation) of IOP in optic associated with glaucoma, ocular hypertension and optic disorders
9) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.84 Pain Relevance 0
The pigmented mice studied by Grozdanic and colleagues [12] showed persistent IOP increases for over 30 days, while in our study, the IOP elevation was restricted to the first week.
Positive_regulation (increases) of IOP associated with ocular hypertension
10) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.23 Pain Relevance 0
Thus, it is of interest to characterize the effects of elevated IOP on retinal neurons.
Positive_regulation (elevated) of IOP in neurons associated with ocular hypertension
11) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.62 Pain Relevance 0
Indeed, different lasering methods result in different IOP elevation profiles with variations in the time at which the peak IOP is reached and maintained, as well as differences in how long ocular hypertension persists [15,30,89].
Positive_regulation (result) of IOP associated with ocular hypertension
12) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.31 Pain Relevance 0
While this may be seen as a disadvantage when compared to a more chronic model of IOP elevation, our IOP profile produced a severe injury to the retina that resulted in several features — loss of RGCs and degeneration of the nerve fiber layer, for example — that are common in an inherited mouse model of ocular hypertension [54-57] commonly used to investigate mechanisms of cell death in glaucomatous optic neuropathy.
Positive_regulation (elevation) of IOP in nerve associated with injury, ocular hypertension, optic disorders and death
13) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.55 Pain Relevance 0
Moreover, we show permanent significant diminution of the scotopic threshold response that is associated with the loss of the great majority of RGCs following elevated IOP; this indicates the value of noninvasive functional ERG measurements to document RGC loss in adult rodents.
Positive_regulation (elevated) of IOP associated with ocular hypertension
14) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.38 Pain Relevance 0
Lasering of the limbal and perilimbal veins resulted in an abrupt increase of IOP, already measurable at 24 h, that persisted until day 5, when IOP started to decrease gradually, reaching preoperative baseline values by one week post-treatment.
Positive_regulation (increase) of IOP in veins associated with ocular hypertension
15) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.29 Pain Relevance 0
The pigmented mice studied by Grozdanic and colleagues [12] showed persistent IOP increases for over 30 days, while in our study, the IOP elevation was restricted to the first week.
Positive_regulation (elevation) of IOP associated with ocular hypertension
16) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 1.16 Pain Relevance 0
It has been largely known that increased IOP may mimic the effect of an axotomy-like injury to RGC axons somewhere near the optic nerve head [26,102-104], where ON axons are highly arranged retinotopically [91,92].
Positive_regulation (increased) of IOP in optic nerve head associated with injury and ocular hypertension
17) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.42 Pain Relevance 0.03
Thus, taken together our present data shows that elevation of IOP in albino mice results in important diminutions of the STR, a-wave, and b-wave amplitudes, which are generated by the innermost, outer and inner nuclear layers of the retina, respectively.
Positive_regulation (elevation) of IOP in retina associated with ocular hypertension
18) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.87 Pain Relevance 0
It is likely that IOP elevation results in permanent damage to the outer retinal layers, because in our experiments, both the a-wave and the b-wave amplitudes diminish soon after lasering and do not recover with time.
Positive_regulation (elevation) of IOP in retinal layers associated with ocular hypertension
19) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.76 Pain Relevance 0
Thus, we have here extended our previous observations in the adult albino rat [26] and further characterized the effects of increased IOP in the retinal neuronal population of adult albino mice.
Positive_regulation (increased) of IOP in neuronal associated with ocular hypertension
20) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.70 Pain Relevance 0

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