INT266893

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.76
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
lung 4
epithelial cells 2
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 227 98.68 Very High Very High Very High
Inflammation 109 95.52 Very High Very High Very High
anesthesia 7 15.56 Low Low
cytokine 26 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Antiepileptic agent 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 179 99.72 Very High Very High Very High
Pulmonary Fibrosis 116 99.08 Very High Very High Very High
INFLAMMATION 97 95.52 Very High Very High Very High
Metaplasia 12 94.92 High High
Stress 49 89.04 High High
Cancer 80 87.68 High High
Injury 10 82.72 Quite High
Bacterial Respiratory Disease 4 73.52 Quite High
Mycoplasma Infection 2 66.40 Quite High
Lung Injury 12 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess whether the reduction in catalase activity in fibrotic lungs is due to the decreased synthesis of catalase, we quantified catalase expression in lung tissues using Western blotting and quantitative RT-PCR.
Spec (whether) Negative_regulation (decreased) of Gene_expression (synthesis) of catalase in lung associated with fibrosis
1) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.58 Pain Relevance 0.09
In contrast, bronchiolar epithelial cells in fibrotic lungs showed decreased catalase expression to various degrees (Figure 2B).
Negative_regulation (decreased) of Gene_expression (expression) of catalase in epithelial cells associated with fibrosis
2) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.61 Pain Relevance 0
We observed that catalase is predominantly expressed in bronchiolar epithelium in normal lungs, and is diminished in IP lungs, especially in bronchiolar epithelium and in abnormal re-epithelialization, such as bronchiolization and squamous metaplasia in humans (Figure 2).
Negative_regulation (diminished) of Gene_expression (expressed) of catalase in lungs associated with metaplasia
3) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.37 Pain Relevance 0.14
Taken together, these findings demonstrate diminished catalase expression and activity in human pulmonary fibrosis and suggest the protective role of catalase against bleomycin-induced inflammation and subsequent fibrosis.



Negative_regulation (diminished) of Gene_expression (expression) of catalase associated with fibrosis, inflammation and pulmonary fibrosis
4) Confidence 0.43 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3022724 Disease Relevance 0.99 Pain Relevance 0.33
Levels of SOD and CAT enzymes were reduced by lead, thus rendering the tissue to the peroxidative damage.
Negative_regulation (reduced) of Gene_expression (Levels) of CAT
5) Confidence 0.42 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964743 Disease Relevance 0.33 Pain Relevance 0
The total cell lysate was prepared using 50 mM phosphate buffer (pH 7.8), which was used to measure SOD expression/activity and catalase expression levels.
Negative_regulation (measure) of Gene_expression (expression) of catalase
6) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.43 Pain Relevance 0
The total cell lysate was prepared using 50 mM phosphate buffer (pH 7.8), which was used to measure SOD expression/activity and catalase expression levels.
Negative_regulation (measure) of Gene_expression (expression) of catalase
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.43 Pain Relevance 0

General Comments

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