INT266894

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.26
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
gastrocnemius 2
skeletal muscle 2
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 16 93.32 High High
Spinal cord 14 83.36 Quite High
Inflammation 114 79.44 Quite High
cytokine 38 78.40 Quite High
Multiple sclerosis 65 77.28 Quite High
Inflammatory response 21 67.28 Quite High
Demyelination 12 62.48 Quite High
medulla 15 58.56 Quite High
ischemia 14 50.08 Quite High
Endocannabinoid 7 41.92 Quite Low
Disease Link Frequency Relevance Heat
Lifespan 25 99.96 Very High Very High Very High
Toxicity 28 99.64 Very High Very High Very High
Alzheimer's Dementia 9 98.96 Very High Very High Very High
Death 41 98.76 Very High Very High Very High
Hepatocellular Cancer 1 91.64 High High
Stress 134 89.84 High High
Frailty 6 83.36 Quite High
Aging 8 81.76 Quite High
INFLAMMATION 141 79.44 Quite High
Drug Induced Neurotoxicity 4 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accordance with the increase in MDA levels, there was a substantial upregulation in antioxidant enzymes, MnSOD (red gastrocnemius, 4-fold; white gastrocnemius, 2.2-fold) and Cu/Zn-SOD (red gastrocnemius, 2.6-fold) in CR vs.
Positive_regulation (increase) of Positive_regulation (upregulation) of MnSOD in gastrocnemius
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.27 Pain Relevance 0
Furthermore, it has been shown that 95 d old G93A mice have significantly elevated levels of MDA (marker of lipid peroxidation) and PC (markers of protein oxidation) in skeletal muscle, as well as a substantial increase in MnSOD, Cu/Zn-SOD and catalase enzyme activity compared with wild-type mice [32].
Positive_regulation (elevated) of Positive_regulation (increase) of MnSOD in skeletal muscle
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.31 Pain Relevance 0
Modest increases in SOD2 are also known to increase lifespan in
Positive_regulation (increase) of Positive_regulation (increases) of SOD2 associated with lifespan
3) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.35 Pain Relevance 0.14
One possible mechanism for “secondary” induction of MnSOD by Nrf2 activation is the upregulation and nuclear translocation of thioredoxin by Nrf2 [33].
Positive_regulation (activation) of Positive_regulation (induction) of MnSOD
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0.05
Chemical UL-induced upregulation of MnSOD in the VN
Positive_regulation (induced) of Positive_regulation (upregulation) of MnSOD
5) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.63 Pain Relevance 0.29
-induced MnSOD activation resulted from an enhanced binding of the dimer p50-p65 to the promoter/enhancer regions of the MnSOD gene [23].
Positive_regulation (induced) of Positive_regulation (activation) of MnSOD
6) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.33 Pain Relevance 0.10
It is likely that MnSOD induction, found in the present study in VN cells after chemical UL, is mediated through activation of NF?
Positive_regulation (mediated) of Positive_regulation (induction) of MnSOD
7) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.36 Pain Relevance 0.10

General Comments

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