INT266895

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 8 57.44 Quite High
Central nervous system 8 55.00 Quite High
Glutamate 1 53.16 Quite High
cytokine 2 47.04 Quite Low
Inflammation 14 21.76 Low Low
Eae 5 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 7 99.08 Very High Very High Very High
Hyperglycemia 55 98.12 Very High Very High Very High
Stress 35 93.20 High High
Neuropathic Pain 1 74.16 Quite High
Disease 4 70.12 Quite High
Diabetes Mellitus 13 61.72 Quite High
Loss Of Sense Of Smell 2 60.56 Quite High
Skin Cancer 7 46.16 Quite Low
Apoptosis 2 31.68 Quite Low
INFLAMMATION 14 21.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During hyperglycemia, excess glucose levels induce over-production of ROS in the mitochondria, which subsequently causes depletion of SOD2 and leads to cellular injury [2], [8]–[10].
Positive_regulation (causes) of Negative_regulation (depletion) of SOD2 associated with hyperglycemia and injury
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.36 Pain Relevance 0.08
This might be due to the interaction between MnSOD and p53, which leads to inactivation of MnSOD activity, as previous studies have demonstrated [36].
Positive_regulation (leads) of Negative_regulation (inactivation) of MnSOD
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0.03

General Comments

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