INT266931

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
colon 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 206 100.00 Very High Very High Very High
Disease 96 97.92 Very High Very High Very High
Colon Cancer 29 97.48 Very High Very High Very High
Ovarian Cancer 51 96.68 Very High Very High Very High
Breast Cancer 169 95.56 Very High Very High Very High
Esophageal Cancer 1 95.44 Very High Very High Very High
Apoptosis 39 93.40 High High
Prostate Cancer 53 90.80 High High
Appetite Loss 2 89.80 High High
Fatigue 13 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding to ligands induces EGFR homo-or heterodimerization
Positive_regulation (induces) of EGFR Binding (heterodimerization) of
1) Confidence 0.50 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.23 Pain Relevance 0
inducing EGFR dimerization with different kinetics, eliciting signals of
Positive_regulation (inducing) of EGFR Binding (dimerization) of
2) Confidence 0.50 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.70 Pain Relevance 0
After ligand binding, the ErbB receptor is activated by di-merization between two identical receptors (homo-dimerization) or between different receptors of the same family (heterodimerization) [28].
Positive_regulation (activated) of ErbB receptor Binding (binding) of
3) Confidence 0.36 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.68 Pain Relevance 0
Epidermal growth factor receptor (EGFR) is overexpressed in 70% of cancers and is associated with chemoresistance, poor prognosis, and advanced disease at presentation [32, 33].
Positive_regulation (overexpressed) of Epidermal growth factor receptor Binding (associated) of associated with cancer and disease
4) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 1.10 Pain Relevance 0
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
Positive_regulation (activated) of EGFR Binding (engagement) of
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.38 Pain Relevance 0
Additionally, CQ has been shown to inhibit the antitumor effect of tephrosin, a natural rotenoid that induces internalization of EGFR and ErbB2, with consequent degradation of these receptors, on colon cancer cells.
Positive_regulation (induces) of EGFR Binding (internalization) of in colon associated with colon cancer
6) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 1.35 Pain Relevance 0

General Comments

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