INT266932

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
MCF7 1
MDA-MB-231 1
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 97 99.76 Very High Very High Very High
Disease 48 99.04 Very High Very High Very High
Ovarian Cancer 50 98.16 Very High Very High Very High
Breast Cancer 117 91.88 High High
Renal Cancer 1 68.08 Quite High
Solid Tumor 7 61.84 Quite High
Toxicity 11 47.28 Quite Low
Apoptosis 9 40.72 Quite Low
Carcinoma 3 40.44 Quite Low
Metastasis 4 39.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Members of the ErbB gene family, respectively, ErbB1, ErbB3, and
Transcription (Members) of ErbB3
1) Confidence 0.43 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.36 Pain Relevance 0
The gemcitabine and pertuzumab trial was performed in patients with platinum resistant EOC, and there was the suggestion of some benefit of pertuzumab in patients with low levels of ERBB3 mRNA expression and platinum-resistant disease; see Table 3.

7.

Transcription (expression) of ERBB3 associated with ovarian cancer and disease
2) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.53 Pain Relevance 0
Three of the lines tested, MCF7, MDA-MB-231 and T47D were found to have elevated levels of both active and total ?
Transcription (found) of MDA-MB-231 in MDA-MB-231
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.41 Pain Relevance 0
Three of the lines tested, MCF7, MDA-MB-231 and T47D were found to have elevated levels of both active and total ?
Transcription (found) of MDA-MB-231 in MCF7
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.41 Pain Relevance 0

General Comments

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