INT26704

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Context Info
Confidence 0.23
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
fat cell 1
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.96 Very High Very High Very High
Potency 2 97.88 Very High Very High Very High
Clonidine 1 92.80 High High
adenocard 1 87.80 High High
agonist 3 87.48 High High
cytokine 8 75.20 Quite High
metalloproteinase 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 9 99.12 Very High Very High Very High
Adhesions 127 93.60 High High
Injury 15 66.52 Quite High
Hypoxia 21 55.08 Quite High
Apoptosis 16 5.00 Very Low Very Low Very Low
Wound Healing 5 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Cicatrix 3 5.00 Very Low Very Low Very Low
Reprotox - General 3 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For alpha-2 antagonists, the potency order was: yohimbine greater than idazoxan greater than SK&F-86,466 much greater than benextramine; 3) a description of the impact of benextramine (irreversible alpha-1/alpha-2 antagonist) on human fat cell alpha-2 adrenergic receptors and on human fat cell function; the drug inactivates the alpha-2 adrenergic receptors with a minor impact on beta adrenergic receptors and without noticeable alterations of fat cell function as assessed by preservation of beta adrenergic and Al-adenosine receptor-mediated lipolytic responses; and 4) a definition of the relationship existing between alpha-2 adrenergic receptor occupancy, inhibition of adenylate cyclase activity and antilipolysis with full and partial agonists.
Transcription (description) of alpha-2 in fat cell associated with adenocard, antagonist, obesity, agonist and potency
1) Confidence 0.23 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2566681 Disease Relevance 0.67 Pain Relevance 0.49
More relevant to the present study are the reports [4,8] on the mRNA levels of human type I collagen (alpha 2), fibronectin 1, MMP-1, TIMP-1, TGF-?
Transcription (levels) of alpha 2
2) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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