INT267071

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
neuroblasts 2
nerve 2
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1 100.00 Very High Very High Very High
allodynia 10 98.18 Very High Very High Very High
Brush evoked pain 15 93.40 High High
Sciatic nerve 1 89.16 High High
Dorsal horn neuron 2 84.80 Quite High
Neuropathic pain 11 78.96 Quite High
Inflammation 17 77.48 Quite High
Pain 18 76.04 Quite High
ischemia 17 59.04 Quite High
Lasting pain 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 19 99.72 Very High Very High Very High
Neuropathic Pain 38 98.18 Very High Very High Very High
Injury 5 88.32 High High
Toxicity 1 78.04 Quite High
INFLAMMATION 16 77.48 Quite High
Pain 35 76.04 Quite High
Neurodegenerative Disease 38 60.56 Quite High
Cv Unclassified Under Development 13 59.04 Quite High
Hypersensitivity 6 49.84 Quite Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the mechanisms underlying the blunted neuropathic allodynia in p2rx4-/- mice requires further investigations, but it may involve a lack of microglial P2X4Rs in the spinal cord, expression of which is markedly upregulated after nerve injury [7,22].
Positive_regulation (upregulated) of Gene_expression (expression) of P2X in nerve associated with nervous system injury, allodynia, neuropathic pain and spinal cord
1) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.58 Pain Relevance 0.95
OGD induced the expression of P2X1 and P2X6 in cortical neuroblasts, while inhibiting P2X6 expression in the SVZ.
Positive_regulation (induced) of Gene_expression (expression) of P2X1 in neuroblasts
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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