INT267095

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 91 95.52 Very High Very High Very High
Spinal cord 48 91.12 High High
fibrosis 5 78.16 Quite High
intrathecal 12 72.32 Quite High
cytokine 19 64.04 Quite High
Inflammation 14 63.64 Quite High
Inflammatory response 5 59.60 Quite High
Lasting pain 4 54.40 Quite High
spinal inflammation 2 52.40 Quite High
Peripheral nerve injury 13 50.28 Quite High
Disease Link Frequency Relevance Heat
Aging 13 99.68 Very High Very High Very High
Osteoarthritis 96 95.52 Very High Very High Very High
Neuropathic Pain 38 93.72 High High
Nervous System Injury 55 89.24 High High
Disease 14 87.44 High High
Fibrosis 7 78.16 Quite High
INFLAMMATION 22 63.64 Quite High
Hypersensitivity 14 62.04 Quite High
Osteoporosis 11 55.92 Quite High
Pain 12 54.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RI/II and the phosphorylation states of receptor-regulated Smad2/3, as well as the expression of the common mediator Smad 4.
Regulation (regulated) of Gene_expression (expression) of Smad2
1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2669449 Disease Relevance 0.88 Pain Relevance 0.56
1 treatment suppressed pSMAD1 and that pSMAD2 levels were unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of pSMAD2
2) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.13 Pain Relevance 0.04
Expression of non phosphorylated Smad2 was not altered during ageing.
Neg (not) Regulation (altered) of Gene_expression (Expression) of Smad2 associated with aging
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.75 Pain Relevance 0.20

General Comments

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