INT2671

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2008
Negated 6
Speculated 5
Reported most in Abstract
Documents 82
Total Number 88
Disease Relevance 11.03
Pain Relevance 29.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
liver 10
brain 6
heart 4
cardiomyocytes 3
immune cells 3
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 88 100.00 Very High Very High Very High
Enkephalin 56 100.00 Very High Very High Very High
narcan 49 100.00 Very High Very High Very High
Hippocampus 16 99.84 Very High Very High Very High
Somatostatin 30 99.76 Very High Very High Very High
Opioid 65 99.74 Very High Very High Very High
Deafferentation 5 99.72 Very High Very High Very High
opioid receptor 50 99.64 Very High Very High Very High
Analgesic 19 99.62 Very High Very High Very High
medulla 11 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stomach Cancer 8 100.00 Very High Very High Very High
Convulsion 40 99.92 Very High Very High Very High
Colon Cancer 8 99.84 Very High Very High Very High
Ulcers 17 99.66 Very High Very High Very High
Pressure And Volume Under Development 8 99.52 Very High Very High Very High
Lymphatic System Cancer 2 99.48 Very High Very High Very High
Cancer 6 98.56 Very High Very High Very High
Apoptosis 9 98.34 Very High Very High Very High
Cv General 4 Under Development 3 98.28 Very High Very High Very High
Necrosis 4 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DFMO completely abolished elevation of ODC activity 6 h after reperfusion but did not change the percentage of fragmented DNA.
Positive_regulation (elevation) of ODC
1) Confidence 0.70 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486179 Disease Relevance 0.81 Pain Relevance 0.35
The present study showed that 2-DG, but not 2,5-AM, increased ODC activity in the peripheral organs, indicating that glucose-metabolism at specific sites of the central nervous system, including the lateral hypothalamus, is important for stimulatory signals to ODC activity.
Positive_regulation (increased) of ODC in lateral associated with central nervous system
2) Confidence 0.70 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782870 Disease Relevance 0 Pain Relevance 0.15
In contrast to 2-DG, infusion of 2,5-AM did not increase ODC activity in the intestinal mucosa or liver.
Neg (not) Positive_regulation (increase) of ODC in liver
3) Confidence 0.70 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782870 Disease Relevance 0 Pain Relevance 0.14
Infusion of 2-DG into the cerebroventricle significantly increased ODC activity in the duodenal and jejunal mucosa and the liver.
Positive_regulation (increased) of ODC in liver
4) Confidence 0.70 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782870 Disease Relevance 0 Pain Relevance 0.14
These results provide the first description of ODC induction in an in vitro preparation of adult brain tissue and indicate that the hippocampal slice preparation could be used to study the molecular mechanisms which regulate the expression and activity of ODC in the adult central nervous system.
Positive_regulation (induction) of ODC in adult central nervous system associated with central nervous system
5) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.43
Moreover the data suggest possible mechanisms which may be involved in the induction of ODC in hippocampus by seizure activity.
Positive_regulation (induction) of ODC in hippocampus associated with convulsion and hippocampus
6) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0.10 Pain Relevance 0.39
Induction of ornithine decarboxylase in adult rat hippocampal slices.
Positive_regulation (Induction) of ornithine decarboxylase associated with enkephalin
7) Confidence 0.70 Published 1988 Journal Brain Res. Section Title Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.40
Although the opiate antagonists naloxone and naltrexone totally blocked the effects of the opioid peptides on ODC induction, they also produced an inhibition of the asparagine-mediated increase in ODC activity.
Positive_regulation (increase) of ODC associated with antagonist, narcan, opiate and opioid
8) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.45
The effect of asparagine was totally blocked by inhibition of either protein or RNA synthesis, suggesting that the inducing amino acids increase ODC activity by stimulating the transcription of genes directly or indirectly regulating ODC activity.
Positive_regulation (increase) of ODC
9) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.30
The same amino acids that have previously been reported to induce ODC in tissue culture, i.e., asparagine and glutamine, were found to produce a concentration- and time-dependent increase in ODC activity that reached a 100 fold the control value after 6 h of incubation.
Positive_regulation (increase) of ODC
10) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.22
In more discrete brain areas (midbrain, brainstem) morphine actually increased ODC activity.
Positive_regulation (increased) of ODC in brainstem associated with medulla, midbrain and morphine
11) Confidence 0.70 Published 1989 Journal Life Sci. Section Abstract Doc Link 2494400 Disease Relevance 0.08 Pain Relevance 1.05
ODC activity is significantly increased 3 hr after the lesions, reaches maximal (50-fold) levels about 12 hr later, and returns to control values after 48 hr.
Positive_regulation (increased) of ODC
12) Confidence 0.70 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.41 Pain Relevance 0.38
These results are consistent with the hypothesis that the early induction of ODC following the initiation of seizures leads to an alteration in genomic expression, which, in turn, changes neuropeptide levels.
Positive_regulation (induction) of ODC associated with convulsion and neuropeptide
13) Confidence 0.70 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.46 Pain Relevance 0.49
The increase occurs in both hippocampi following unilateral electrolytic lesions, is blocked by treatments that suppress limbic seizures, and does not occur after lesions that fail to elicit seizures; accordingly, we conclude that the increase in ODC activity results from epileptiform activity rather than some other consequence of the hilar lesion (e.g., deafferentation).
Positive_regulation (increase) of ODC associated with convulsion and deafferentation
14) Confidence 0.70 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.49 Pain Relevance 0.49
Induction of ornithine decarboxylase as a possible mediator of seizure-elicited changes in genomic expression in rat hippocampus.
Spec (possible) Positive_regulation (Induction) of ornithine decarboxylase in hippocampus associated with convulsion, enkephalin and hippocampus
15) Confidence 0.70 Published 1986 Journal J. Neurosci. Section Title Doc Link 3794781 Disease Relevance 0.39 Pain Relevance 0.54
The increase in ODC activity precedes the increase in the amount of mRNA coding for the enkephalin prohormone, which, in turn, precedes the increase in enkephalin levels.
Positive_regulation (increase) of ODC associated with enkephalin
16) Confidence 0.70 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.48 Pain Relevance 0.51
ODC activity in the intestine was increased when intraluminal pressure was increased and 3 h after placing cholera toxin in the intestinal lumen.
Positive_regulation (increased) of ODC in intestinal lumen associated with vibrio infection
17) Confidence 0.69 Published 1993 Journal Acta Physiol. Scand. Section Abstract Doc Link 8128898 Disease Relevance 0.19 Pain Relevance 0.07
Sympathetic stimulation elevates heart ornithine decarboxylase (ODC) activity in adult rats, an effect which is followed by cardiac hypertrophy.
Positive_regulation (elevates) of ODC in heart associated with coronary heart disease
18) Confidence 0.69 Published 1978 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 633081 Disease Relevance 0.10 Pain Relevance 0.40
The effect of the peptide was antagonized by an opiate antagonist naloxone. 5000 micrograms/kg of dalargin failed to inhibit the ulcer formation or to activate ornithine decarboxylase.
Neg (failed) Positive_regulation (activate) of ornithine decarboxylase associated with antagonist, ulcers, narcan and opiate
19) Confidence 0.69 Published 1987 Journal Biull Eksp Biol Med Section Abstract Doc Link 3828514 Disease Relevance 0.26 Pain Relevance 0.28
Conversely, subcutaneous administration of beta-endorphin increased ODC activity in the heart and liver.
Positive_regulation (increased) of ODC in liver
20) Confidence 0.69 Published 1986 Journal Life Sci. Section Abstract Doc Link 2941633 Disease Relevance 0 Pain Relevance 0.28

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