INT267108

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD3) signal transducer activity (DRD3)
DRD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 20 100.00 Very High Very High Very High
Dopamine 94 98.16 Very High Very High Very High
Nicotine 184 86.36 High High
positron emission tomography 8 82.88 Quite High
addiction 70 72.04 Quite High
Serotonin 62 65.60 Quite High
withdrawal 24 63.84 Quite High
Hippocampus 4 54.24 Quite High
Nucleus accumbens 4 41.00 Quite Low
gABA 4 37.08 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 344 99.80 Very High Very High Very High
Depression 20 5.00 Very Low Very Low Very Low
Alcohol Addiction 20 5.00 Very Low Very Low Very Low
Neurosis 14 5.00 Very Low Very Low Very Low
Drug Dependence 8 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 8 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, smoking may create a vicious cycle of reward and deficiency; a recent study found that smoking seems to inhibit dopamine receptor D3 mRNA expression, thereby diminishing the rewarding effect of dopamine, leading to a reward deficiency state and creating motivation for continued smoking [37].
Negative_regulation (inhibit) of Gene_expression (expression) of dopamine receptor D3 mRNA associated with dopamine, nicotine addiction and dopamine receptor
1) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.77 Pain Relevance 0.84
Furthermore, smoking may create a vicious cycle of reward and deficiency; a recent study found that smoking seems to inhibit dopamine receptor D3 mRNA expression, thereby diminishing the rewarding effect of dopamine, leading to a reward deficiency state and creating motivation for continued smoking [37].
Negative_regulation (inhibit) of Gene_expression (expression) of dopamine receptor D3 mRNA associated with dopamine, nicotine addiction and dopamine receptor
2) Confidence 0.26 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.77 Pain Relevance 0.84

General Comments

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