INT267112

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.21
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
neurons 1
podocytes 1
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 16 96.52 Very High Very High Very High
Neurotransmitter 2 70.48 Quite High
imagery 6 62.16 Quite High
Serotonin 3 50.00 Quite Low
Dopamine 8 11.64 Low Low
depression 1 10.24 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 118 99.40 Very High Very High Very High
Open-angle Glaucoma 34 99.24 Very High Very High Very High
Congenital Anomalies 17 90.48 High High
Glaucoma 56 88.64 High High
Disease 6 87.48 High High
Targeted Disruption 12 87.20 High High
Ocular Hypertension 94 81.44 Quite High
Eye Malformation 2 77.44 Quite High
Cataract 20 49.84 Quite Low
Hypotension 14 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several well-known NPS studies have reported cosegregation of OAG and NPS as a result of a pleiotropic effect of the LMX1B gene in different families [1-3,14].
Regulation (effect) of LMX1B associated with syndrome and open-angle glaucoma
1) Confidence 0.61 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.41 Pain Relevance 0
In contrast, the expression of both Pet1 and Aadc appeared unchanged in Lmx1b iCKO mice relative to control mice, indicating that there was no loss of 5-HTergic neurons in the raphe nuclei.
Neg (unchanged) Spec (appeared) Regulation (unchanged) of Lmx1b in neurons associated with raphe
2) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.13
It has been suggested that as the LMX1B gene encodes a LIM homeodomain transcription factor, which contributes to transcriptional regulation of glomerular membrane collagen expression by podocytes, both renal and ocular malformations could result from the same alteration during embryogenesis.
Regulation (contributes) of LMX1B in podocytes
3) Confidence 0.45 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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