INT267113

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
neuron 2
basement membrane 2
Pet1 2
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 95.28 Very High Very High Very High
Raphe 48 84.04 Quite High
Dopamine 24 73.80 Quite High
Locus ceruleus 6 60.36 Quite High
depression 3 52.56 Quite High
Ventral tegmentum 3 52.12 Quite High
Substantia nigra 3 51.04 Quite High
Serotonin 9 50.00 Quite Low
monoamine 6 39.56 Quite Low
Somatosensory cortex 3 6.32 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 99.96 Very High Very High Very High
Congenital Anomalies 11 96.40 Very High Very High Very High
Eye Malformation 1 96.24 Very High Very High Very High
Glaucoma 28 94.32 High High
Syndrome 59 84.24 Quite High
Disease 3 71.60 Quite High
Cleidocranial Dysplasia 2 58.00 Quite High
Mental Disorders 9 54.64 Quite High
Depression 3 52.56 Quite High
Post-traumatic Stress Disorder 3 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Pet1 in the 5-HTergic neurons leads to a decrease of Tph2 expression but no change in Lmx1b expression.
Neg (no) Regulation (change) of Gene_expression (expression) of Lmx1b in Pet1
1) Confidence 0.62 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.16 Pain Relevance 0.15
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Regulation (flanked) of Gene_expression (allele) of Lmx1b
2) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.18
Deleting Lmx1b in the adult brain results in down-regulation of 5-HTergic neuron-associated genes
Regulation (regulation) of Gene_expression (Deleting) of Lmx1b in neuron
3) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
The abnormal expression of collagen in homozygous lmx1b knockout mice may explain the split in the glomerular basement membrane in the kidney or the eye abnormalities [18,19] possibly related with glaucoma.
Regulation (abnormal) of Gene_expression (expression) of lmx1b in basement membrane associated with eye malformation, targeted disruption and glaucoma
4) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.20 Pain Relevance 0

General Comments

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