INT267114

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.96
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
neurons 3
brain 1
adult brain 1
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 80 97.52 Very High Very High Very High
Dopamine 40 73.60 Quite High
anesthesia 6 65.80 Quite High
monoamine 10 59.68 Quite High
imagery 3 51.04 Quite High
Serotonin 15 50.00 Quite Low
Locus ceruleus 10 48.36 Quite Low
Raphe magnus 5 41.24 Quite Low
medulla 15 40.56 Quite Low
Ventral tegmentum 5 40.12 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 59 96.40 Very High Very High Very High
Glaucoma 28 91.76 High High
Targeted Disruption 15 91.12 High High
Open-angle Glaucoma 17 70.88 Quite High
Ocular Hypertension 47 70.32 Quite High
Body Weight 15 67.76 Quite High
Renal Disease 4 27.80 Quite Low
Hypotension 7 27.68 Quite Low
Cleidocranial Dysplasia 2 26.20 Quite Low
Congenital Anomalies 13 25.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we failed to provide direct morphological data showing the deletion of Lmx1b, based on the data mentioned above and phenotypes observed in Lmx1b iCKO mice, it is reasonable to speculate that Lmx1b is inactivated in 5-HTergic neurons of Lmx1b iCKO mice.
Positive_regulation (inactivated) of Lmx1b in neurons
1) Confidence 0.50 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.06
Taken together, we conclude that Lmx1b is required for normal expression of 5-HT in adult brain.


Positive_regulation (required) of Lmx1b in adult brain
2) Confidence 0.50 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10
Furthermore, Pet1 expression in 5-HTergic neurons requires Lmx1b during embryonic development [12], but its expression in the raphe nuclei of Lmx1b iCKO mice showed no difference from wild-type controls (Figure 5Q–T).
Positive_regulation (requires) of Lmx1b in neurons associated with raphe
3) Confidence 0.50 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.20
We found that the number of Aadc-expressing neurons was unchanged in Lmx1b iCKO mice compared with controls (Figures 5M–P, 6), consistent with the finding that similar Lmx1b immunostaining was present in both Lmx1b iCKO and wild-type mice (Figure S1).
Neg (unchanged) Positive_regulation (unchanged) of Lmx1b in neurons
4) Confidence 0.50 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.12
To delete Lmx1b in the adult mouse brain, we crossed mice carrying two floxed Lmx1b alleles with mice harboring a tamoxifen-inducible form of Cre recombinase (CreERT2) [13] under the control of the Pet1 promoter, to generate Lmx1b iCKO mice (Figure 1A).
Positive_regulation (generate) of Lmx1b in brain
5) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.21 Pain Relevance 0.10
NPS is caused by a mutation in the LMX1B gene that presumably leads to loss of function of the encoding transcription factor, and the clinical phenotype is related to the pleiotropic effect of LMX1B during development [20,21].
Positive_regulation (effect) of LMX1B associated with syndrome
6) Confidence 0.40 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

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