INT267148

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
endothelial cells 4
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 77.76 Quite High
Nicotine 20 70.36 Quite High
Inflammation 62 66.96 Quite High
Inflammatory response 10 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 186 93.36 High High
Nicotine Addiction 366 91.52 High High
INFLAMMATION 74 66.96 Quite High
Disease 50 5.00 Very Low Very Low Very Low
Chronic Obstructive Pulmonary Disease 44 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 32 5.00 Very Low Very Low Very Low
Periodontal Disease 22 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Carcinoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, CSC increased the migration of monocytic cells across HUVECs and bovine aorta endothelial cells, concomitant with an up to 10-fold increase in PECAM-1 phosphorylation, which was inhibited by PKC inhibitors.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PECAM-1 in endothelial cells
1) Confidence 0.37 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.18 Pain Relevance 0.14
Furthermore, CSC increased the migration of monocytic cells across HUVECs and bovine aorta endothelial cells, concomitant with an up to 10-fold increase in PECAM-1 phosphorylation, which was inhibited by PKC inhibitors.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PECAM-1 in endothelial cells
2) Confidence 0.37 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.18 Pain Relevance 0.14

General Comments

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