INT267185

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.48
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb8) intracellular (Hspb8) response to stress (Hspb8)
cytoplasm (Hspb8)
Anatomy Link Frequency
cardiomyocytes 2
eosinophil 2
mast cell 2
Hspb8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 220 91.00 High High
cytokine 28 77.36 Quite High
fibrosis 15 56.32 Quite High
Central nervous system 3 34.80 Quite Low
adenocard 4 23.12 Low Low
chemokine 4 22.60 Low Low
tolerance 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Nicotine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 96 99.96 Very High Very High Very High
Coronary Heart Disease 90 99.16 Very High Very High Very High
Disease 37 98.52 Very High Very High Very High
Death 36 97.16 Very High Very High Very High
Targeted Disruption 288 95.72 Very High Very High Very High
Airway Remodeling 16 94.40 High High
Hyperplasia 16 93.40 High High
Apoptosis 15 91.32 High High
INFLAMMATION 188 91.00 High High
Asthma 384 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While we have shown that HSPB1 and HSPB8 can directly interrupt amyloid oligomer formation caused by HSPB5 R120G and restore cellular viability in cardiomyocytes expressing HSPB5 R120G, the in vivo protective effects of the small HSPs on the development of DRM remain unproven.
HSPB8 Binding (interrupt) of in cardiomyocytes associated with alzheimer's dementia and coronary heart disease
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.41 Pain Relevance 0.03
Our previous in vitro study showed that HSPB8 and HSPB1, which can bind to HSPB5 R120G, inhibited amyloid oligomer formation and reduced cell death in the R120G transfected cardiomyocytes [15].
HSPB8 Binding (bind) of in cardiomyocytes associated with alzheimer's dementia and death
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0
We have shown that HSPB8 can directly interact with HSPB5 R120G and inhibit amyloid oligomer and aggresome formation [15].
HSPB8 Binding (interact) of associated with alzheimer's dementia
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.94 Pain Relevance 0
Binding of IgE, crosslinked with allergen, induces eosinophil and mast cell degranulation.
IgE Binding (crosslinked) of in mast cell
4) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.68 Pain Relevance 0.17
Binding of IgE, crosslinked with allergen, induces eosinophil and mast cell degranulation.
IgE Binding (Binding) of in mast cell
5) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.68 Pain Relevance 0.17
Binding of IgE, crosslinked with allergen, induces eosinophil and mast cell degranulation.
IgE Binding (crosslinked) of in eosinophil
6) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.68 Pain Relevance 0.17
Binding of IgE, crosslinked with allergen, induces eosinophil and mast cell degranulation.
IgE Binding (Binding) of in eosinophil
7) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2831838 Disease Relevance 0.68 Pain Relevance 0.17

General Comments

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