INT26719

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 11.87
Pain Relevance 22.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 6
substantia nigra 6
brainstem 6
VLM 4
midbrain 4
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 96 100.00 Very High Very High Very High
withdrawal 56 100.00 Very High Very High Very High
Substantia nigra 52 100.00 Very High Very High Very High
Enkephalin 39 100.00 Very High Very High Very High
Ventral tegmentum 36 100.00 Very High Very High Very High
medulla 34 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
Cholecystokinin 13 100.00 Very High Very High Very High
noradrenaline 7 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 28 99.82 Very High Very High Very High
Toxocariasis 9 98.78 Very High Very High Very High
Kernicterus 14 98.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 98.32 Very High Very High Very High
Aids-related Complex 3 98.32 Very High Very High Very High
Infantile Spasms 26 97.44 Very High Very High Very High
Hypercapnia 5 96.96 Very High Very High Very High
Lissencephaly 4 96.92 Very High Very High Very High
Nociception 1 96.40 Very High Very High Very High
Hypertension 8 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TH immunoreactivity was increased in the NTS/VLM after induction of morphine withdrawal, whereas there was a decrease in TH levels in the PVN.
Negative_regulation (decrease) of Gene_expression (levels) of TH in VLM associated with toxocariasis, withdrawal and morphine
1) Confidence 0.58 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.50 Pain Relevance 1.61
These data indicate that the endogenous opioid peptides are an integral component for increasing PRL release in response to suckling and they act to decrease tuberoinfundibular dopaminergic neuronal activity during lactation, in part, by suppressing TH gene expression.
Negative_regulation (suppressing) of Gene_expression (expression) of TH gene in neuronal associated with endogenous opioid
2) Confidence 0.58 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607794 Disease Relevance 0.15 Pain Relevance 0.17
Tyrosine hydroxylase (TH) expression in medial basal hypothalamus (MBH) protein extracts was lowered by pretreatment with mifepristone, with no additional effect of naloxone.
Negative_regulation (lowered) of Gene_expression (expression) of TH in MBH
3) Confidence 0.57 Published 2006 Journal Neuroendocrinology Section Body Doc Link 17090971 Disease Relevance 0 Pain Relevance 0
The pretreatment with actinomycin D (0.5 mg/kg) significantly decreased CHX-induced proENK and TH mRNA expression, suggesting that the CHX-dependent increase of these mRNA levels may be caused by the increase of transcriptional activity rather than RNA stabilization.
Negative_regulation (decreased) of Gene_expression (expression) of TH mRNA
4) Confidence 0.56 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.21
Tyrosine hydroxylase mRNA expression is selectively reduced only in the substantia nigra by perinatal morphine.
Negative_regulation (reduced) of Gene_expression (expression) of Tyrosine hydroxylase mRNA in substantia nigra associated with substantia nigra and morphine
5) Confidence 0.53 Published 1996 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8884380 Disease Relevance 0 Pain Relevance 0.99
Agmatine inhibited morphine-induced changes in dynorphin, but not in tyrosine hydroxylase mRNA expression.
Negative_regulation (inhibited) of Gene_expression (expression) of tyrosine hydroxylase mRNA associated with dynorphin and morphine
6) Confidence 0.43 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17604969 Disease Relevance 0 Pain Relevance 1.69
When HA-1004 (40 nmol/day), inhibitor of cyclic AMP dependent protein kinase (PKA) was infused, concomitantly with morphine, it diminished the increase in noradrenaline (NA) turnover, total TH expression (95.76 +/- 4.1 %, P < 0.01) and TH phosphorylation at Ser40 (85.5 +/- 11%, P < 0.01) in morphine-withdrawn rats.
Negative_regulation (diminished) of Gene_expression (expression) of TH associated with noradrenaline and morphine
7) Confidence 0.43 Published 2009 Journal Basic Res. Cardiol. Section Abstract Doc Link 19104749 Disease Relevance 0.06 Pain Relevance 1.24
TH immunoreactivity in the NTS/VLM was increased 90 min after morphine withdrawal, whereas there was a decrease in TH levels in the PVN at the same time point.
Negative_regulation (decrease) of Gene_expression (levels) of TH in VLM associated with toxocariasis, withdrawal and morphine
8) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534973 Disease Relevance 0.53 Pain Relevance 1.57
METHODS: Immunohistochemical double-staining method was used to co-localize TH and Fos expression in neurons of the rat brainstem in visceral or subcutaneous noxious stimulation models.
Negative_regulation (co-localize) of Gene_expression (expression) of TH in brainstem
9) Confidence 0.41 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 12717853 Disease Relevance 0.10 Pain Relevance 0
These results suggest that the basal expression of proENK and TH mRNA transcription in the adrenal gland seems to be tonically inhibited by de novo protein synthesis.
Negative_regulation (inhibited) of Gene_expression (expression) of TH mRNA in adrenal gland
10) Confidence 0.41 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.24
Immunocytochemical methods were used to define the distribution of enkephalin (ENK), substance P (SP), tyrosine hydroxylase (TH), and serotonin (5-hydroxytryptamine: 5HT) in the rat septum.
Negative_regulation (define) of Gene_expression (distribution) of TH associated with 5ht, enkephalin, serotonin and substance p
11) Confidence 0.41 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6202728 Disease Relevance 0 Pain Relevance 0.84
Immunocytochemical methods were used to define the distribution of enkephalin (ENK), substance P (SP), tyrosine hydroxylase (TH), and serotonin (5-hydroxytryptamine: 5HT) in the rat septum.
Negative_regulation (define) of Gene_expression (distribution) of tyrosine hydroxylase associated with 5ht, enkephalin, serotonin and substance p
12) Confidence 0.41 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6202728 Disease Relevance 0 Pain Relevance 0.84
On days 16 and 31, tyrosine hydroxylase gene expression in ventral tegmental area and substantia nigra and cannabinoid CB1 receptor gene expression in the CPu decreased (approximately 45-50% from vehicle).
Negative_regulation (decreased) of Gene_expression (expression) of tyrosine hydroxylase in substantia nigra associated with ventral tegmentum, cannabinoid and substantia nigra
13) Confidence 0.40 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15936043 Disease Relevance 0.10 Pain Relevance 0.96
Therefore, our data demonstrate the neuroprotective properties of mildronate against a 6-OHDA-induced loss of TH expression.
Negative_regulation (loss) of Gene_expression (expression) of TH
14) Confidence 0.40 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.06 Pain Relevance 0.07
SL327, an inhibitor of ERK activation, at doses which reduced the hyperactive pERK(1/2) levels, did not attenuated the rise in pCREB and TH immunoreactivity or plasma corticosterone secretion during morphine withdrawal, indicating that ERK kinase/ERK pathway was not directly needed for either activation of CREB and TH expression in the NTS or HPA axis hyperactivity.
Neg (not) Negative_regulation (attenuated) of Gene_expression (immunoreactivity) of TH in plasma associated with attention deficit hyperactivity disorder, withdrawal and morphine
15) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.23 Pain Relevance 1.22
The results indicate that PKC mediates both CREB activation and HPA response by morphine withdrawal and might suggest that CREB activation in the NTS is related to TH expression associated with morphine withdrawal.
Negative_regulation (related) of Gene_expression (expression) of TH associated with kinase c, withdrawal and morphine
16) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.14 Pain Relevance 1.04
In contrast, PKC inhibitor calphostin C reduced the withdrawal-triggered rise in pCREB, pERK(1/2), TH expression and corticosterone secretion.
Negative_regulation (reduced) of Gene_expression (expression) of TH associated with kinase c and withdrawal
17) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.16 Pain Relevance 1.14
Dopamine release may also be increased as indicated by a higher metabolism and consequent reduction of tyrosine hydroxylase mRNA expression in the substantia nigra.
Negative_regulation (reduction) of Gene_expression (expression) of tyrosine hydroxylase mRNA in substantia nigra associated with dopamine and substantia nigra
18) Confidence 0.39 Published 1996 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8884380 Disease Relevance 0 Pain Relevance 0.99
The chronic morphine-induced increases in ERK activity and TH expression in the VTA also were blocked by local infusion of NMDA glutamate receptor antagonists, suggesting a role for glutamate in mediating these drug effects.
Negative_regulation (blocked) of Gene_expression (expression) of TH associated with ventral tegmentum, glutamate, antagonist, glutamate receptor and morphine
19) Confidence 0.38 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.09 Pain Relevance 1.23
While the loss of TH following GMA-MS was transient, a sustained loss (34%) was observed in the midbrain 105 days after cessation of MMA-HS exposure.
Negative_regulation (loss) of Gene_expression (following) of TH in midbrain associated with midbrain
20) Confidence 0.36 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.57 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox