INT267197

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 5 86.48 High High
anesthesia 3 40.64 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 34 98.84 Very High Very High Very High
Targeted Disruption 96 96.24 Very High Very High Very High
Coronary Heart Disease 30 94.24 High High
Fibrosis 5 86.48 High High
Disease 11 83.76 Quite High
Renal Disease 78 50.00 Quite Low
Exsanguination 2 39.64 Quite Low
Diabetes Mellitus 104 10.40 Low Low
Injury 3 8.96 Low Low
Stress 26 7.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we show that geranylgeranylacetone (GGA), a nontoxic antiulcer drug and inducer of small HSPs [16], can induce expression of HSPB8 and HSPB1 and reduce the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
Positive_regulation (induce) of Gene_expression (expression) of HSPB1 associated with targeted disruption and alzheimer's dementia
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.43 Pain Relevance 0.04
M) stimulated total HSP25 protein expression the most (data not shown) and was therefore used for all subsequent experiments.
Positive_regulation (stimulated) of Gene_expression (expression) of HSP25 protein
2) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
A time-dependent titration further demonstrated that treating cells with Cur for 60-70 min stimulated HSP25 protein expression (data not shown).
Positive_regulation (stimulated) of Gene_expression (expression) of HSP25 protein
3) Confidence 0.44 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0

General Comments

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