INT2672

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Context Info
Confidence 0.25
First Reported 1979
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RT1-EC2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 16 100.00 Very High Very High Very High
alcohol 2 95.88 Very High Very High Very High
tetrodotoxin 1 90.88 High High
Dopamine 1 78.60 Quite High
Morphine 2 59.28 Quite High
methadone 1 44.00 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 2 96.60 Very High Very High Very High
Decapitation 1 75.76 Quite High
Alcohol Addiction 1 75.00 Quite High
Stress 1 42.16 Quite Low
Appetite Loss 1 41.52 Quite Low
Hypoglycemia 1 37.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cerebellar aspartyl aminotransferase (EC 2.6.1.1) activity was reduced at day 11 and 14 in ethanol treated pups compared with controls.
Negative_regulation (reduced) of EC 2.6.1.1
1) Confidence 0.25 Published 1979 Journal Brain Res. Section Abstract Doc Link 497836 Disease Relevance 0.26 Pain Relevance 0.09
On L-[3,5-3H]tyrosine (1 microM) superfusion, high K+ (15 and 60 mM) released DOPA and DA together with concentration-dependent decreases in tyrosine 3-monooxygenase (EC 1.14.16.2) activity as indicated by [3H]H2O formation, followed by concentration-dependent increases after DOPA and DA release ended.
Negative_regulation (decreases) of EC 1.14.16.2
2) Confidence 0.21 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2897424 Disease Relevance 0 Pain Relevance 0.13
One method was based on the irreversible inhibition of GABA transaminase (EC 2.6.1.19) by microinjection of gamma-vinyl-GABA into neostriatum of rat.
Negative_regulation (inhibition) of EC 2.6.1.19 associated with gaba
3) Confidence 0.14 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3555508 Disease Relevance 0.08 Pain Relevance 0.47

General Comments

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