INT267202

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.80
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
HSF 6
nucleus 4
hearts 1
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 30 92.76 High High
Demyelination 20 71.68 Quite High
unmyelinated 14 70.76 Quite High
Central nervous system 6 50.56 Quite High
hypoalgesia 8 50.00 Quite Low
diabetic neuropathy 4 28.00 Quite Low
qutenza 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 87 100.00 Very High Very High Very High
Stress 127 99.66 Very High Very High Very High
Targeted Disruption 580 98.96 Very High Very High Very High
Apoptosis 92 95.52 Very High Very High Very High
Neurodegenerative Disease 34 95.48 Very High Very High Very High
Fibrosis 30 92.76 High High
Insulin Resistance 4 91.36 High High
Coronary Heart Disease 180 87.00 High High
Death 107 83.04 Quite High
Diabetes Mellitus 80 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mammalian cells, induction of HSP70 requires activation and nuclear localization of HSF-1 [30], [31].
Localization (localization) of HSF-1 in HSF
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.63 Pain Relevance 0.03
Since it is known that protein interaction between heat shock factor (HSF) and HSP70, as well as nuclear translocation of HSF is important for HSP induction by GGA [20], the effect of GGA on HSF1 localization was examined (Figure 3F).
Localization (localization) of HSF1 in HSF associated with shock
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.67 Pain Relevance 0.08
However, further enhancement of HSP70 induction by GGA treatment was modest in these hearts and HSF1 was already translocated into nuclei in the R120G TG mice in this study.
Localization (translocated) of HSF1 in hearts associated with targeted disruption
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.52 Pain Relevance 0
Although transcriptional activity of the HSF1 is uncertain, depending on the location of HSF1 as assessed immunohistochemically, the HSP70-HSF interaction is not sufficient to explain GGA's effects completely.
Localization (location) of HSF1 in HSF
4) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.42 Pain Relevance 0
Since it is known that protein interaction between heat shock factor (HSF) and HSP70, as well as nuclear translocation of HSF is important for HSP induction by GGA [20], the effect of GGA on HSF1 localization was examined (Figure 3F).
Localization (translocation) of heat shock factor in HSF associated with shock
5) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.65 Pain Relevance 0.08
In mammalian cells, induction of HSP70 requires activation and nuclear localization of HSF-1 [30], [31].
Localization (localization) of HSF-1 in HSF
6) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.63 Pain Relevance 0.03
Since small-molecule N-terminal Hsp90 inhibitors can mimic cell stress and promote the release of HSF1 from Hsp90 (Blagg and Kerr, 2006), their ability to decrease protein aggregation has been proposed for treating neurodegenerative diseases whose aetiology is linked to the accumulation of specific misfolded or aggregated proteins (Luo et al., 2007; Luo et al., 2008).
Localization (release) of HSF1 associated with stress and neurodegenerative disease
7) Confidence 0.52 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.83 Pain Relevance 0
The reliance on Hsp70 expression for neuroprotection suggests that if KU-32 promotes a broader HSR via the release of HSF-1, this is not sufficient for drug efficacy.
Localization (release) of HSF-1 in HSF
8) Confidence 0.46 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.93 Pain Relevance 0.07
Therefore, increase in ERK1/2 activity by Resveratrol provided another negative influence on Hsp70 levels through negative regulation of HSF1 activity. 17-allylamino-17-demethoxygeldanamycin (17AAG), a drug that inhibits Hsp90 chaperone and degrades its client protein Akt concomitantly elevated Hsp70 levels by promoting nuclear translocation of HSF1 from the cytosol.
Localization (translocation) of HSF1
9) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.20 Pain Relevance 0
in presence of Resveratrol definitely contributes to the blocking of HSF1 translocation to the nucleus and hence Hsp70 expression.
Localization (translocation) of HSF1 in nucleus
10) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Measuring the levels of cytosolic and nuclear fraction of HSF1 by Western blot analysis, it was found that exposure to 0.5µM Wortmanin for 24h appreciably augmented the cytosolic localization of HSF1 which showed a further increase at 1µM concentration.
Localization (localization) of HSF1
11) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.15 Pain Relevance 0
Thus Akt pathway controls the translocation of HSF1 to the nucleus.
Localization (translocation) of HSF1 in nucleus
12) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Also, the HSF1 translocation to the nucleus was abrogated by Wortmanin at concentration as low as 0.5µM.
Localization (translocation) of HSF1 in nucleus
13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0
Measuring the levels of cytosolic and nuclear fraction of HSF1 by Western blot analysis, it was found that exposure to 0.5µM Wortmanin for 24h appreciably augmented the cytosolic localization of HSF1 which showed a further increase at 1µM concentration.
Localization (fraction) of HSF1
14) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.16 Pain Relevance 0
The HSF1 activation and translocation to the nucleus is dependent on phosphorylation of its multiple amino acid residues [32].
Localization (translocation) of HSF1 in nucleus
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0

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