INT267215

Context Info Confidence 0.25 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 7.19 Pain Relevance 0

cytoplasm (Cryab, Hspb1) nucleus (Cryab, Hspb1) plasma membrane (Cryab, Hspb1) unfolded protein binding (Cryab) mitochondrion (Cryab) Golgi apparatus (Cryab)

Anatomy Link Frequency cardiomyocytes 1 Cryab (Mus musculus) Hspb1 (Mus musculus) Cryab - R120G (3)

Pain Link Frequency Relevance Heat fibrosis 20 13.20 Central nervous system 4 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 128 100.00 Coronary Heart Disease 120 97.92 Death 48 97.52 Apoptosis 20 90.92 Toxicity 16 86.60 Targeted Disruption 384 81.16 Disease 28 78.92 Injury 4 51.56 Stress 24 50.32 Neurodegenerative Disease 16 46.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].

HSPB5 Binding (interrupt) of HSPB1 associated with alzheimer's dementia

1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.96 Pain Relevance 0

In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].

HSPB5 (R120G) Binding (interrupt) of HSPB1 associated with alzheimer's dementia

2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.96 Pain Relevance 0

Our previous in vitro study showed that HSPB8 and HSPB1, which can bind to HSPB5 R120G, inhibited amyloid oligomer formation and reduced cell death in the R120G transfected cardiomyocytes [15].

HSPB5 (R120G) Binding (bind) of HSPB1 in cardiomyocytes associated with alzheimer's dementia and death

3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0

In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].

HSPB5 (R120G) Binding (interrupt) of HSPB1 associated with alzheimer's dementia

4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.85 Pain Relevance 0

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