INT267215

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 7.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cryab, Hspb1) nucleus (Cryab, Hspb1) plasma membrane (Cryab, Hspb1)
unfolded protein binding (Cryab) mitochondrion (Cryab) Golgi apparatus (Cryab)
Anatomy Link Frequency
cardiomyocytes 1
Cryab (Mus musculus)
Hspb1 (Mus musculus)
Cryab - R120G (3)
Pain Link Frequency Relevance Heat
fibrosis 20 13.20 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 128 100.00 Very High Very High Very High
Coronary Heart Disease 120 97.92 Very High Very High Very High
Death 48 97.52 Very High Very High Very High
Apoptosis 20 90.92 High High
Toxicity 16 86.60 High High
Targeted Disruption 384 81.16 Quite High
Disease 28 78.92 Quite High
Injury 4 51.56 Quite High
Stress 24 50.32 Quite High
Neurodegenerative Disease 16 46.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].
HSPB5 Binding (interrupt) of HSPB1 associated with alzheimer's dementia
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.96 Pain Relevance 0
In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].
HSPB5 (R120G) Binding (interrupt) of HSPB1 associated with alzheimer's dementia
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.96 Pain Relevance 0
Our previous in vitro study showed that HSPB8 and HSPB1, which can bind to HSPB5 R120G, inhibited amyloid oligomer formation and reduced cell death in the R120G transfected cardiomyocytes [15].
HSPB5 (R120G) Binding (bind) of HSPB1 in cardiomyocytes associated with alzheimer's dementia and death
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0
In our previous study, we showed that recombinant HSPB8 or HSPB1 protein could directly interrupt HSPB5 R120G-mediated amyloid oligomer formation although amyloid oligomer is still present in the mixture of wild-type (WT) HSPB5 and mutant HSPB5 R120G [15].
HSPB5 (R120G) Binding (interrupt) of HSPB1 associated with alzheimer's dementia
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.85 Pain Relevance 0

General Comments

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