INT267217

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.80
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb8, Casp3) intracellular (Hspb8, Casp3) cytoplasm (Hspb8, Casp3)
cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
Anatomy Link Frequency
cardiomyocyte 6
Hspb8 (Mus musculus)
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 10 84.28 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 98.64 Very High Very High Very High
Targeted Disruption 192 97.92 Very High Very High Very High
Alzheimer's Dementia 64 95.12 Very High Very High Very High
Apoptosis 10 87.20 High High
Fibrosis 10 84.28 Quite High
Coronary Heart Disease 60 76.96 Quite High
Disease Progression 2 75.76 Quite High
Heart Disease 6 66.12 Quite High
Muscle Disease 2 52.60 Quite High
Shock 8 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both GGA treatment and overexpression of HSPB8 resulted in inhibition of cytochrome c release from mitochondria, decreased activation of caspase-3 and attenuated TUNEL-positive cardiomyocyte death in R120G TG mice (Figure 8A–D).
Gene_expression (overexpression) of HSPB8 in cardiomyocyte Negative_regulation (decreased) of Positive_regulation (activation) of caspase-3 in cardiomyocyte associated with targeted disruption and death
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.88 Pain Relevance 0
Treatment with GGA as well as the overexpression of HSPB8 also inhibited cytochrome c release from mitochondria, activation of caspase-3 and TUNEL-positive cardiomyocyte death in the R120G TG mice.


Gene_expression (overexpression) of HSPB8 in cardiomyocyte Negative_regulation (inhibited) of Positive_regulation (activation) of caspase-3 in cardiomyocyte associated with death
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2670514 Disease Relevance 0.92 Pain Relevance 0.04

General Comments

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