INT267269

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 62
Total Number 69
Disease Relevance 48.75
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BCL11B) intracellular (BCL11B)
Anatomy Link Frequency
neck 6
head 6
skin 5
epithelium 3
stem cells 3
BCL11B (Homo sapiens)
Pain Link Frequency Relevance Heat
projection neuron 4 99.36 Very High Very High Very High
Glutamate 4 91.44 High High
GABAergic 4 79.76 Quite High
gABA 2 76.60 Quite High
Neurotransmitter 2 73.84 Quite High
Spinal cord 6 49.84 Quite Low
midbrain 18 40.24 Quite Low
Pain 67 24.88 Low Low
alcohol 134 8.88 Low Low
Action potential 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5569 99.96 Very High Very High Very High
Cleidocranial Dysplasia 402 99.80 Very High Very High Very High
Targeted Disruption 67 99.80 Very High Very High Very High
Squamous Cell Carcinoma 268 99.28 Very High Very High Very High
Carcinoma 201 99.00 Very High Very High Very High
Neuroblastoma 67 99.00 Very High Very High Very High
Injury 134 98.90 Very High Very High Very High
Volume Depletion And Dehydration 67 98.76 Very High Very High Very High
Eczema 67 98.12 Very High Very High Very High
Wound Healing 201 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTIP2 expression was undetectable in some cell lines from umbilical cord endothelium (HUVEC), skin and tongue fibroblast (GM3348 & HS677Tg).
Gene_expression (expression) of CTIP2 in skin
1) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.69 Pain Relevance 0
The analyses of CTIP2 expression were independently performed by two investigators.
Gene_expression (expression) of CTIP2
2) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.25 Pain Relevance 0
CTIP2 expression was found to be significantly elevated in HNSCC (p<0.01), and increase in CTIP2 expression was associated with poorly differentiated tumor status.
Gene_expression (expression) of CTIP2 associated with cancer
3) Confidence 0.78 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.69 Pain Relevance 0
The mechanisms of differential expression of CTIP2 and regulation of gene expression by CTIP2 in HNSCC remain to be elucidated.
Gene_expression (expression) of CTIP2
4) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.69 Pain Relevance 0
Altogether, our results suggest existence of distinct subsets of cancer cells which express CTIP2 and underscore the use of CTIP2 and BMI1 co-labeling to identify tumor initiating cancer stem cells (CSC).


Gene_expression (express) of CTIP2 in stem cells associated with cancer
5) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.58 Pain Relevance 0
Stronger and homogeneous expression of CTIP2 was observed in moderately and/or poorly differentiated tumors (Figs. 1E–H) compared to the well differentiated tumors.
Gene_expression (expression) of CTIP2 associated with cancer
6) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.74 Pain Relevance 0
We also evaluated CTIP2 expression pattern by immunohistochemistry (IHC) and qRT-PCR, and determined correlation between clinicopathological factors and CTIP2 expression in a panel of human HNSCC samples.


Gene_expression (expression) of CTIP2
7) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.97 Pain Relevance 0
Expression of CTIP2 in human cell lines
Gene_expression (Expression) of CTIP2
8) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.57 Pain Relevance 0
It has been already shown that CTIP2 is widely expressed in normal mouse skin [19].
Gene_expression (expressed) of CTIP2 in skin
9) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.50 Pain Relevance 0
Poorly differentiated tumors which are less differentiated contain more proliferative cells, and hence have higher CTIP2 expression.
Gene_expression (expression) of CTIP2 associated with cancer
10) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.82 Pain Relevance 0
Some, but not all, of the cells present within hair follicle bulge were also found to co-express CTIP2, keratin K15, but not CD34, indicating that a subset of K15+ CD34?
Neg (not) Gene_expression (express) of CTIP2 in hair follicle
11) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.49 Pain Relevance 0
Since CTIP2 was upregulated in our wound healing experiments and as wound healing and cancer have key similarities where cancer is defined as “wound that never heals” [22], we were interested to look at CTIP2 expression in HNSCC.
Gene_expression (expression) of CTIP2 associated with cancer, injury and wound healing
12) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.94 Pain Relevance 0
The main aim of this work is to understand the cellular and molecular basis of CTIP2 overexpression in HNSCC and to establish it as a novel biomarker in human HNSCC.
Gene_expression (overexpression) of CTIP2
13) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.90 Pain Relevance 0
Altogether, our results with K10 and Ki-67 shows that CTIP2 expression is linked to tumor differentiation state and proliferation.
Gene_expression (expression) of CTIP2 associated with cancer
14) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.76 Pain Relevance 0
In the present study we found lower CTIP2 expression in more differentiated tumor type and CTIP2 expression increased with loss of differentiation.
Gene_expression (expression) of CTIP2 associated with cancer
15) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.90 Pain Relevance 0
In the present study, we analyzed CTIP2 expression in human HNSCC cell lines by western blotting, in paraffin embedded archival specimens by immunohistochemistry (IHC), and in cDNA samples of human HNSCC by qRT-PCR.
Spec (analyzed) Gene_expression (expression) of CTIP2
16) Confidence 0.78 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.54 Pain Relevance 0
CTIP2 expression was found to be significantly elevated in HNSCC (p<0.01), and increase in CTIP2 expression was associated with poorly differentiated tumor status.
Gene_expression (expression) of CTIP2 associated with cancer
17) Confidence 0.78 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.70 Pain Relevance 0
Recently, it has been shown that CTIP2 is expressed early during mouse development as well as in the adult animal, and in both cases, expression is most predominant in the skin/epithelial structures, CNS and thymus [19], [20].
Gene_expression (expressed) of CTIP2 in thymus
18) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.46 Pain Relevance 0
Dramatic increase in CTIP2 expression was found in dysplasia where expression was observed all the way up to the differentiating cell layers, compared to the normal where expression was restricted to the basal cell layer.
Gene_expression (expression) of CTIP2 in basal cell associated with cleidocranial dysplasia
19) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.92 Pain Relevance 0
We also evaluated CTIP2 expression pattern by immunohistochemistry (IHC) and qRT-PCR, and determined correlation between clinicopathological factors and CTIP2 expression in a panel of human HNSCC samples.


Gene_expression (expression) of CTIP2
20) Confidence 0.78 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.98 Pain Relevance 0

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