INT26729

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Context Info
Confidence 0.55
First Reported 1983
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 28
Total Number 32
Disease Relevance 9.32
Pain Relevance 15.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 4
substantia nigra 1
brain 1
basal ganglia 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 481 100.00 Very High Very High Very High
dopamine receptor 67 100.00 Very High Very High Very High
antagonist 60 100.00 Very High Very High Very High
Kinase C 10 100.00 Very High Very High Very High
agonist 89 99.76 Very High Very High Very High
depression 7 99.58 Very High Very High Very High
GABAergic 14 99.52 Very High Very High Very High
Glutamate 71 99.48 Very High Very High Very High
Dynorphin 13 99.28 Very High Very High Very High
Neurotransmitter 23 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 8 99.58 Very High Very High Very High
Parkinson's Disease 11 99.48 Very High Very High Very High
Targeted Disruption 71 99.26 Very High Very High Very High
Disease 74 99.20 Very High Very High Very High
Cluster Headache 6 99.20 Very High Very High Very High
Cv General 3 Under Development 1 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 23 98.52 Very High Very High Very High
Schizophrenia 19 98.08 Very High Very High Very High
Macromastia 1 98.08 Very High Very High Very High
Cognitive Disorder 51 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Negative_regulation (regulation) of D2 dopamine receptor associated with dopamine receptor, mu opioid receptor and enkephalin
1) Confidence 0.55 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101360 Disease Relevance 0 Pain Relevance 0.87
This was accompanied by a decrease in the level of D2 receptor messenger RNA in striatum as measured by Northern analysis.
Negative_regulation (decrease) of D2 receptor in striatum
2) Confidence 0.55 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101360 Disease Relevance 0 Pain Relevance 0.64
Furthermore, this observation prompted us to investigate the dopaminergic autoreceptor function in the absence of D2 receptor in D2R-/- mice.
Spec (investigate) Negative_regulation (absence) of D2 receptor
3) Confidence 0.43 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.86
The lack of ERK activation in neurons expressing D2R may result from a negative effect of D2R on ERK activation, since pharmacological blockade of D2Rs by haloperidol or raclopride selectively activates ERK and induces histone H3 phosphorylation in D2R-expressing striatopallidal MSNs in the dorsal striatum (Bertran-Gonzalez et al., 2008, 2009).
Negative_regulation (effect) of D2R in striatum
4) Confidence 0.43 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.32
We studied in vivo the influence of flunarizine on dopamine D2 receptors and investigated whether dopamine D2 receptor blockade is involved in its antimigraine action.
Spec (whether) Negative_regulation (blockade) of dopamine D2 receptor associated with cluster headache and dopamine
5) Confidence 0.42 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954746 Disease Relevance 0.34 Pain Relevance 0.37
There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls.
Negative_regulation (reduction) of dopamine D2 receptor associated with dopamine
6) Confidence 0.42 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954746 Disease Relevance 0.35 Pain Relevance 0.40
These results suggest that the absence of D2R alters the GABAergic neurotransmission, specifically on GABA(A)-receptor mediated signaling, and stimulating the GABA(A) receptor can reverse the dysfunction of GABAergic inhibition in the motor circuits in the basal ganglia.
Negative_regulation (absence) of D2R in basal ganglia associated with gaba and gabaergic
7) Confidence 0.41 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080900 Disease Relevance 0.15 Pain Relevance 0.68
To study the functions of each dopamine receptors, mice lacking each of D1R, D2R, D3R and D4R dopamine receptors have been generated.
Negative_regulation (lacking) of D2R associated with dopamine receptor
8) Confidence 0.40 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803208 Disease Relevance 0.64 Pain Relevance 0.35
Mice lacking the D2 dopamine receptor (D2(-/-)) and congenic to the C57BL/6J background were tested for opioid-mediated locomotor activity to examine the involvement of the D2 dopamine receptor in opioid pharmacology.
Negative_regulation (lacking) of D2 dopamine receptor associated with eae, dopamine receptor and opioid
9) Confidence 0.40 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16125819 Disease Relevance 0 Pain Relevance 0.86
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Negative_regulation (down-regulation) of D2 receptor associated with dopamine receptor, mu opioid receptor and enkephalin
10) Confidence 0.40 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101360 Disease Relevance 0 Pain Relevance 0.88
Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.
Negative_regulation (decreases) of D2 dopamine receptor in striatum associated with dopamine receptor, mu opioid receptor, agonist and enkephalin
11) Confidence 0.40 Published 1993 Journal Neuroscience Section Title Doc Link 8101360 Disease Relevance 0 Pain Relevance 0.76
Indeed, the neurochemical effects of cocaine and morphine are unchanged in animals with a selective deletion of the long isoform D2L receptor.
Negative_regulation (deletion) of D2L receptor associated with morphine and cocaine
12) Confidence 0.38 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943831 Disease Relevance 0 Pain Relevance 0.82
An absence of opioid-rewarding effects has been reported in mice lacking DRD2 [7].
Negative_regulation (lacking) of DRD2 associated with opioid
13) Confidence 0.38 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.75 Pain Relevance 0.43
Striatal mRNA levels for PPE, PDyn, and DRD1 and DRD2 receptors revealed a significant change in the expression of markers present in medium spiny neurons projecting to the substantia nigra (direct pathway).
Negative_regulation (receptors) of DRD2 in substantia nigra associated with substantia nigra
14) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.37
However, unlike SHR, striatal DRD2 autoreceptors controlling dopamine synthesis are nonfunctional while DRD1 and DRD2 are downregulated by approximately 50% in the striatum of DAT-KO mice [171].
Negative_regulation (downregulated) of DRD2 in striatum associated with dopamine
15) Confidence 0.29 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.65 Pain Relevance 0.47
Indeed, D1 and D2 receptor as well as preproenkephalin A mRNA levels were decreased from G14 on, and dynorphin mRNA level was increased from G17 on.
Negative_regulation (decreased) of D2 receptor associated with dynorphin
16) Confidence 0.28 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.69
In patients with Huntington's disease, mainly postsynaptic dysfunctions with reductions of striatal D1 (six out of six reports) and D2 receptor binding (15 out of 15 reports) were observed.
Negative_regulation (reductions) of D2 receptor associated with disease
17) Confidence 0.24 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19523490 Disease Relevance 1.19 Pain Relevance 0.14
In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 receptors.
Negative_regulation (blocker) of dopamine D2 associated with dopamine and antinociceptive
18) Confidence 0.18 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575800 Disease Relevance 0.09 Pain Relevance 0.81
Dysregulation of glutamate release is compounded by loss of DA D2, CB1, mGluR2/3 and other presynaptic receptors regulating glutamate release at corticostriatal terminals.
Negative_regulation (loss) of D2 associated with glutamate
19) Confidence 0.10 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.09 Pain Relevance 0.43
Flunarizine also has dopamine D2 receptor blocking properties and was effective in animal models of predictive validity for antipsychotics.
Negative_regulation (blocking) of dopamine D2 receptor associated with dopamine
20) Confidence 0.10 Published 2008 Journal J Clin Psychiatry Section Abstract Doc Link 19192440 Disease Relevance 0.46 Pain Relevance 0.24

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