INT2673

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Context Info
Confidence 0.57
First Reported 1979
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 93
Total Number 95
Disease Relevance 50.34
Pain Relevance 12.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
plasma 4
MCF-7 2
brain 2
globular structures 2
dendrites 1
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 745 100.00 Very High Very High Very High
cytokine 105 100.00 Very High Very High Very High
Paracetamol 10 100.00 Very High Very High Very High
potassium channel 10 99.84 Very High Very High Very High
Neurotransmitter 11 99.80 Very High Very High Very High
tolerance 440 99.72 Very High Very High Very High
Arthritis 9 99.58 Very High Very High Very High
ischemia 284 99.04 Very High Very High Very High
Lamotrigine 1 98.78 Very High Very High Very High
diclofenac 8 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 791 100.00 Very High Very High Very High
Prostate Cancer 187 100.00 Very High Very High Very High
Hypoxia 161 99.98 Very High Very High Very High
Pancreatitis 543 99.88 Very High Very High Very High
Infection 12 99.86 Very High Very High Very High
Renal Cancer 3 99.84 Very High Very High Very High
Hemorrhage 52 99.76 Very High Very High Very High
Inflammatory Bowel Disease 189 99.68 Very High Very High Very High
Sepsis 142 99.68 Very High Very High Very High
Edema 67 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein C and Protein S are reduced at birth to 30% of adult plasma concentrations and remain decreased during the first weeks of life [5].
Negative_regulation (reduced) of Protein C in plasma
1) Confidence 0.57 Published 2006 Journal Thromb J Section Body Doc Link PMC1533804 Disease Relevance 0.49 Pain Relevance 0.04
Pressure conditioning also results in suppression of the compression rate effect on Pc.
Negative_regulation (suppression) of Pc
2) Confidence 0.49 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 3804908 Disease Relevance 0.26 Pain Relevance 0.32
Protein C and Protein S are reduced at birth to 30% of adult plasma concentrations and remain decreased during the first weeks of life [5].
Negative_regulation (decreased) of Protein C in plasma
3) Confidence 0.42 Published 2006 Journal Thromb J Section Body Doc Link PMC1533804 Disease Relevance 0.55 Pain Relevance 0.04
Protein C deficiency is one of several hereditary abnormalities of haemostatic proteins that have been described in patients with propensities to thromboembolic complications.
Negative_regulation (deficiency) of Protein C associated with congenital anomalies and cva
4) Confidence 0.42 Published 2004 Journal Thromb J Section Body Doc Link PMC415559 Disease Relevance 0.72 Pain Relevance 0.12
Protein C and protein S levels were depressed but antithrombin-3 was normal (6%, 16% and 111%; respectively).
Negative_regulation (depressed) of Protein C
5) Confidence 0.42 Published 2004 Journal Thromb J Section Body Doc Link PMC415559 Disease Relevance 0.57 Pain Relevance 0.15
The PC was reversibly inactivated by the stereotaxic administration of tetrodotoxin (TTX) 60 min before saccharin drinking, immediately after saccharin drinking (Experiment 1), 6 or 24 hr after LiCl administration (Experiment 2), and 60 min before CTA retrieval testing (Experiment 3).
Negative_regulation (inactivated) of PC associated with appetite loss and tetrodotoxin
6) Confidence 0.41 Published 2000 Journal Behav. Neurosci. Section Abstract Doc Link 11085601 Disease Relevance 0.59 Pain Relevance 0.10
If PC was administered simultaneously with ascorbic acid (AA), also in a dose of 3 X 1000 mg, a decreased level of UDS was observed after 24, 72 and 168 h and the increased number of micronuclei was qualitatively the same as the PC alone: 0.38 +/- 0.09% after 72 h vs. 0.20 +/- 0.05% at 0 h AA did not decrease the genotoxic effect of PC, but prolonged the influence of PC on UDS.
Neg (not) Negative_regulation (decrease) of PC associated with paracetamol
7) Confidence 0.38 Published 1989 Journal Mutat. Res. Section Abstract Doc Link 2811932 Disease Relevance 0 Pain Relevance 0.80
Only pre-saccharin drinking PC inactivation disrupted CTA.
Negative_regulation (inactivation) of PC associated with appetite loss
8) Confidence 0.36 Published 2000 Journal Behav. Neurosci. Section Abstract Doc Link 11085601 Disease Relevance 0.61 Pain Relevance 0.09
It thus seems that, in patients developing MOF, the PC activation system reached its limits prior to the diagnosis of MOF, resulting in secondary deficiency of PC concomitantly with a failure to maintain steady APC levels similar to those observed in AP patients without MOF.
Negative_regulation (deficiency) of PC associated with multiple organ failure and pancreatitis
9) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.55 Pain Relevance 0.07
This suggestion, however, does not exclude the possibility that significant PC deficiency could also be rate limiting for APC formation in patients with severe AP, as seems to be the case in septic children [17].
Negative_regulation (deficiency) of PC associated with pancreatitis
10) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.81 Pain Relevance 0
Namely, there was no indication that PC deficiency would associate with MOF after its diagnosis and, further, there was a significant trend for improvement of PC homeostasis during the course of MOF.
Negative_regulation (deficiency) of PC associated with multiple organ failure
11) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.55 Pain Relevance 0.03
Thus, in logical accordance with animal AP data and human sepsis studies, early PC deficiency was a most frequent finding during severe AP.
Negative_regulation (deficiency) of PC associated with pancreatitis and sepsis
12) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.33 Pain Relevance 0
During cardiopulmonary bypass, upon rapid thrombin generation during reperfusion, the APC/PC correlation was lost and a significant positive correlation between fibrinopetide A, a thrombin marker, and APC developed [24].
Negative_regulation (lost) of PC
13) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.33 Pain Relevance 0
The patient series was rather uniform in disease severity and the incidence of MOF approached 50%, however, giving us the opportunity to test the hypothesis of whether a defective PC pathway would be detrimental to patients with AP.
Spec (whether) Negative_regulation (defective) of PC associated with multiple organ failure, pancreatitis and disease
14) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.86 Pain Relevance 0
The PC deficiency was therefore logically associated with a decrease of APC levels in patients with MOF.
Negative_regulation (deficiency) of PC associated with multiple organ failure
15) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.83 Pain Relevance 0
The seronegative spondyloarthropathies (ankylosing spondylitis, psoriatic arthritis, Reiter's syndrome and arthritis associated with chronic inflammatory bowel diseases) are distinguished by inflammatory lesions of the sacroiliac joints, of the spine and/or a peripheral arthritis associated with the absence of rheumatoid factors.
Negative_regulation (absence) of factors in spine associated with seronegative spondarthritis, spinal inflammation, inflammation, syndrome and arthritis
16) Confidence 0.24 Published 1990 Journal Schweiz Med Wochenschr Section Abstract Doc Link 2188353 Disease Relevance 0.68 Pain Relevance 0.38
Vitamin K deficiency in this patient was considered to have been caused by cephem antibiotics containing N-methyl-thiotetrazole (NMTT) side chain and no oral intake of food for a few days preoperatively.
Negative_regulation (deficiency) of Vitamin K
17) Confidence 0.22 Published 2007 Journal Masui Section Abstract Doc Link 17315736 Disease Relevance 1.19 Pain Relevance 0.33
Decreased PC values (defined as <70% of the normal plasma pool) were a frequent finding; found in 43% of all samples (68% of all patients) at various stages of the disease (Figure 1a).
Negative_regulation (Decreased) of PC in plasma associated with disease
18) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.09 Pain Relevance 0
A decreased PC level was observed in 92% of cases and in 44% of controls (P = 0.008).
Negative_regulation (decreased) of PC
19) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.24 Pain Relevance 0
In an animal model of AP, the PC level was found to decline already one hour after initiation of AP [29].
Negative_regulation (decline) of PC associated with pancreatitis
20) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.16 Pain Relevance 0

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