INT26732

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Context Info
Confidence 0.28
First Reported 1989
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 96.20 Very High Very High Very High
cINOD 1 60.92 Quite High
Kinase C 3 30.80 Quite Low
Clonidine 1 19.08 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 60.68 Quite High
Poisoning 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade by lipoxygenase inhibitors of Ca2+-dependent insulin secretion from permeabilized rat islets.
Negative_regulation (inhibitors) of Localization (secretion) of lipoxygenase
1) Confidence 0.28 Published 1989 Journal Biochem. Pharmacol. Section Title Doc Link 2567595 Disease Relevance 0 Pain Relevance 0.05
In 3-oxo-TA-challenged PMNs, the mitogen-activated protein kinase kinase (MEK)-1/2 inhibitor PD098059 abolished 5-LO product formation, along with inhibition of MEK-1/2 phosphorylation and 5-LO translocation.
Negative_regulation (inhibition) of Localization (translocation) of 5-LO
2) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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