INT26732

Context Info Confidence 0.28 First Reported 1989 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.06 Pain Relevance 0.11

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5) nucleus (Alox5) cytoplasm (Alox5)

Alox5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 2 96.20 cINOD 1 60.92 Kinase C 3 30.80 Clonidine 1 19.08

Disease Link Frequency Relevance Heat INFLAMMATION 1 60.68 Poisoning 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blockade by lipoxygenase inhibitors of Ca2+-dependent insulin secretion from permeabilized rat islets.

Negative_regulation (inhibitors) of Localization (secretion) of lipoxygenase

1) Confidence 0.28 Published 1989 Journal Biochem. Pharmacol. Section Title Doc Link 2567595 Disease Relevance 0 Pain Relevance 0.05

In 3-oxo-TA-challenged PMNs, the mitogen-activated protein kinase kinase (MEK)-1/2 inhibitor PD098059 abolished 5-LO product formation, along with inhibition of MEK-1/2 phosphorylation and 5-LO translocation.

Negative_regulation (inhibition) of Localization (translocation) of 5-LO

2) Confidence 0.03 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11455013 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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