INT26733

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 5.74
Pain Relevance 13.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal cord 6
spinal 4
neurons 1
cleavage 1
heart 1
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 36 100.00 Very High Very High Very High
Dorsal horn 5 99.84 Very High Very High Very High
Morphine 70 99.52 Very High Very High Very High
Spinal cord 36 99.52 Very High Very High Very High
nMDA receptor antagonist 5 99.50 Very High Very High Very High
withdrawal 24 99.44 Very High Very High Very High
intrathecal 23 98.58 Very High Very High Very High
tolerance 32 98.56 Very High Very High Very High
narcan 9 97.88 Very High Very High Very High
Neuropathic pain 5 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 7 100.00 Very High Very High Very High
Bordatella Infection 2 99.08 Very High Very High Very High
Poisoning 1 98.00 Very High Very High Very High
Primary Sclerosing Cholangitis 8 97.62 Very High Very High Very High
Neuropathic Pain 6 97.52 Very High Very High Very High
INFLAMMATION 35 95.16 Very High Very High Very High
Apoptosis 9 91.16 High High
Depression 1 88.40 High High
Affective Disorder 1 87.64 High High
Necrosis 1 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since phospholipase C activation can also lead to the production of the protein kinase C activator diacylglycerol, we have undertaken experiments to see whether acutely applied desipramine could change the synaptic strength of neurons in a protein kinase C-dependent manner.
Gene_expression (production) of protein kinase in neurons associated with desipramine and kinase c
1) Confidence 0.48 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218774 Disease Relevance 0.18 Pain Relevance 0.70
These results demonstrate that selective reduction in the expression of the spinal protein kinase Calpha isozyme followed by a decrease of local protein kinase C-mediated phosphorylation will reverse spinal morphine infusion-induced tolerance.
Gene_expression (expression) of protein kinase in spinal associated with kinase c, tolerance and morphine
2) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.48
Intrathecal treatment with the antisense, but not the missense, in rats decreased expression of spinal protein kinase Calpha mRNA and protein, as revealed by real-time quantitative reverse transcription-polymerase chain reaction and western blots.
Gene_expression (expression) of protein kinase in spinal associated with intrathecal
3) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.62
Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance.
Gene_expression (expression) of protein kinase in spinal associated with tolerance and morphine
4) Confidence 0.41 Published 2002 Journal Neuroscience Section Title Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.36
In the present study, we examined the effect of intrathecal delivery of an antisense oligonucleotide targeting rat protein kinase Calpha mRNA on the expression of spinal protein kinase Calpha isozyme and spinal morphine tolerance.
Gene_expression (expression) of protein kinase in spinal associated with tolerance, morphine and intrathecal
5) Confidence 0.35 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.20
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
6) Confidence 0.30 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.43 Pain Relevance 0.65
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
7) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.50 Pain Relevance 0.70
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
8) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.51 Pain Relevance 0.70
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
9) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.44 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
10) Confidence 0.26 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.44 Pain Relevance 0.65
Interestingly, the majority of pCREB-IR cells expressed protein kinase Cgamma, an enzyme shown to be involved in the development of neuropathic pain in PSNL model.
Gene_expression (expressed) of protein kinase associated with neuropathic pain
11) Confidence 0.13 Published 2001 Journal Pain Section Abstract Doc Link 11514088 Disease Relevance 0.81 Pain Relevance 0.99
These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release.
Gene_expression (produced) of protein kinase associated with nmda receptor antagonist, narcan and morphine
12) Confidence 0.11 Published 1997 Journal J Toxicol Sci Section Abstract Doc Link 9076657 Disease Relevance 0 Pain Relevance 1.28
These data support a causal relationship between protein kinase A- or C-dependent signal transduction, nociceptive afferent- or NK1R-induced neuronal excitation and Fos expression in dorsal horn.
Gene_expression (expression) of protein kinase in dorsal horn associated with nociception and dorsal horn
13) Confidence 0.08 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11553293 Disease Relevance 0.15 Pain Relevance 0.42
Our previous studies have shown that morphine withdrawal induced an increase in the expression of protein kinase (PK) A and mitogen-activated extracellular kinase (MAPK) pathways in the heart during morphine withdrawal.
Gene_expression (expression) of protein kinase in heart associated with withdrawal and morphine
14) Confidence 0.08 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 0.81
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
Gene_expression (synergism) of protein kinase associated with kinase c and poisoning
15) Confidence 0.07 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.10 Pain Relevance 0.29
Sensitization of PSC with culture duration was accompanied by increased expression of CD95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH-terminal cleavage product of receptor-interacting protein.
Gene_expression (expression) of kinase B in cleavage associated with primary sclerosing cholangitis
16) Confidence 0.06 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12181199 Disease Relevance 1.72 Pain Relevance 0.07
The aim of the present study was to examine the effect of intrathecal (i.t.) injection of pertussis toxin (PTX) on the nociceptive threshold and protein kinase C (PKC) expression in the rat spinal cord.
Gene_expression (expression) of protein kinase in spinal cord associated with nociception, kinase c, bordatella infection, spinal cord and intrathecal
17) Confidence 0.05 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.46 Pain Relevance 0.34

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