INT26735

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 2003
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.56
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal 2
spinal cord 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 12 100.00 Very High Very High Very High
intrathecal 8 100.00 Very High Very High Very High
Spinal cord 4 99.52 Very High Very High Very High
Morphine 12 98.92 Very High Very High Very High
tolerance 8 98.56 Very High Very High Very High
withdrawal 2 89.68 High High
Clonidine 1 79.44 Quite High
agonist 2 78.44 Quite High
analgesia 1 75.52 Quite High
Thermal hyperalgesia 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 100.00 Very High Very High Very High
Nociception 1 100.00 Very High Very High Very High
Poisoning 1 98.00 Very High Very High Very High
Hyperalgesia 5 75.00 Quite High
Increased Venous Pressure Under Development 1 62.56 Quite High
Decapitation 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined the effect of intrathecal delivery of an antisense oligonucleotide targeting rat protein kinase Calpha mRNA on the expression of spinal protein kinase Calpha isozyme and spinal morphine tolerance.
Spec (examined) Regulation (effect) of Gene_expression (expression) of protein kinase in spinal associated with tolerance, morphine and intrathecal
1) Confidence 0.24 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.21
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
Regulation (effects) of Gene_expression (synergism) of protein kinase associated with kinase c and poisoning
2) Confidence 0.05 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.10 Pain Relevance 0.29
The aim of the present study was to examine the effect of intrathecal (i.t.) injection of pertussis toxin (PTX) on the nociceptive threshold and protein kinase C (PKC) expression in the rat spinal cord.
Spec (examine) Regulation (effect) of Gene_expression (expression) of protein kinase in spinal cord associated with nociception, kinase c, bordatella infection, spinal cord and intrathecal
3) Confidence 0.03 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560106 Disease Relevance 0.46 Pain Relevance 0.34

General Comments

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