INT26737

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Context Info
Confidence 0.06
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.30

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cytoplasm (Alox5, Ins1) cytosol (Alox5) extracellular space (Ins1)
nuclear envelope (Alox5) extracellular region (Ins1) oxidoreductase activity (Alox5)
Alox5 (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 89.64 High High
agonist 2 88.64 High High
Kinase C 3 87.88 High High
Disease Link Frequency Relevance Heat
Poisoning 1 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
lipoxygenase Regulation (modulates) of Localization (release) of insulin associated with kinase c and poisoning
1) Confidence 0.06 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.09 Pain Relevance 0.30

General Comments

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