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Context Info
Confidence 0.06
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Alox5, Ins1) cytosol (Alox5) extracellular space (Ins1)
nuclear envelope (Alox5) extracellular region (Ins1) oxidoreductase activity (Alox5)
Alox5 (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 89.64 High High
agonist 2 88.64 High High
Kinase C 3 87.88 High High
Disease Link Frequency Relevance Heat
Poisoning 1 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that (1) islet lipoxygenase is constitutively expressed and is not physiologically regulated by alpha 2-adrenergic agonism, Ca2+ or protein kinases; (2) lipoxygenase modulates insulin release; HETE production is not merely an epiphenomenon reflecting the activation (or inhibition) of exocytotic secretion; (3) islet lipoxygenase inhibitors reduce insulin secretion, at least in part, by blocking the direct effects of Ca2+ on exocytosis and/or its synergism with Ca2+-binding proteins such as protein kinase C; and (4) these same inhibitors do not directly poison protein kinase C or A, or the exocytotic apparatus.
lipoxygenase Regulation (modulates) of Localization (release) of insulin associated with kinase c and poisoning
1) Confidence 0.06 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2567595 Disease Relevance 0.09 Pain Relevance 0.30

General Comments

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