INT26750

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.46
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Anatomy Link Frequency
blood 1
fibroblast 1
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 4 99.38 Very High Very High Very High
dexamethasone 166 95.48 Very High Very High Very High
Morphine 172 94.88 High High
Eae 7 93.52 High High
Physical dependence 10 90.48 High High
cytokine 10 87.76 High High
Desipramine 1 76.56 Quite High
fluoxetine 1 75.52 Quite High
tolerance 8 75.20 Quite High
Pain 1 68.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 49 99.72 Very High Very High Very High
Frailty 17 99.72 Very High Very High Very High
Stress 7 99.52 Very High Very High Very High
Infection 108 98.44 Very High Very High Very High
Breast Cancer 7 97.52 Very High Very High Very High
Sprains And Strains 178 96.36 Very High Very High Very High
Cancer 48 95.96 Very High Very High Very High
Lymphatic System Cancer 3 90.92 High High
Influenza Virus Infection 3 90.68 High High
Drug Dependence 12 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In males 24 hr after adrenalectomy there was a clear 2- to 2.5-fold increase (upregulation) in glucocorticoid receptor number.
Positive_regulation (increase) of glucocorticoid receptor
1) Confidence 0.46 Published 1989 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 2568122 Disease Relevance 0.23 Pain Relevance 0
GC functions are primarily mediated by the glucocorticoid receptor (GR) that is encoded by the Nr3c1 gene.
Positive_regulation (encoded) of glucocorticoid receptor
2) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.12 Pain Relevance 0.03
Moreover, transcriptional activation of a pattern of co-expressed genes (for instance, Tsc22d3 and Nfkbia) was identified as being mediated via the glucocorticoid receptor (GR).
Positive_regulation (activation) of glucocorticoid receptor
3) Confidence 0.14 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.48 Pain Relevance 1.21
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (required) of glucocorticoid receptor associated with breast cancer and apoptosis
4) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.67 Pain Relevance 0.27
The aim of the present study was to investigate effects of some classical and new antidepressants on functional activity of the glucocorticoid receceptor (GR) induced by low corticosterone concentration in mouse fibroblast cells stably transfected with mouse mammary tumor virus-chloramphenicol acetyltransferase plasmid (LMCAT cells).
Positive_regulation (induced) of glucocorticoid receceptor in fibroblast associated with antidepressant and cancer
5) Confidence 0.05 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.20
One major consideration regarding thymus atrophy is a rise of glucocorticoid hormone level in the blood, which is induced due to the stress responses to severe infections [43,44,51,52].
Positive_regulation (induced) of glucocorticoid hormone in blood associated with stress, frailty and infection
6) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.87 Pain Relevance 0.04

General Comments

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