INT267568

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.36
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) cytoplasm (PTPN11)
Anatomy Link Frequency
arms 1
platelets 1
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 81.68 Quite High
dexamethasone 1 57.00 Quite High
addiction 2 50.00 Quite Low
midbrain 20 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 99.06 Very High Very High Very High
Purpura 1 60.52 Quite High
Thrombocytopenia 1 60.20 Quite High
Cancer 39 55.44 Quite High
Dengue 41 50.00 Quite Low
Apoptosis 14 46.76 Quite Low
Adverse Drug Reaction 3 23.44 Low Low
Infection 21 5.00 Very Low Very Low Very Low
Fever 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the NS1 and NS2 blocks could precede a US or a BKG block, we labeled them PreUS-NS and PreBKG-NS, respectively.
Negative_regulation (blocks) of NS1
1) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671607 Disease Relevance 0 Pain Relevance 0
Calling rate during the US stimulus blocks was 21±6 calls/min compared with a baseline rate of 0±0.15 calls/min during NS1 and BKG blocks.
Negative_regulation (blocks) of NS1
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671607 Disease Relevance 0 Pain Relevance 0
Time to resolution of NS1 antigenaemia was not significantly different between CQ and placebo arms (Fig. 3A) (HR?
Negative_regulation (resolution) of NS1 in arms
3) Confidence 0.19 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919376 Disease Relevance 0 Pain Relevance 0
NSC87877 is a potent inhibitor of Shp2, a phosphatase known to promote several signaling pathways (22, 24–26).
Negative_regulation (inhibitor) of Shp2
4) Confidence 0.10 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.09 Pain Relevance 0
This inhibitor has previously been found by Chen et al. (27) to reduce viability of a breast cancer cell line, and they also detected an NSC87877 inhibition of EGF-induced Shp2 activity in these cells.
Negative_regulation (inhibition) of Shp2 associated with breast cancer
5) Confidence 0.10 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.10 Pain Relevance 0
PTPi IV has been shown amongst others to be a potent inhibitor of Shp2 (37), as has also NSC87877.
Negative_regulation (inhibitor) of Shp2
6) Confidence 0.10 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.06 Pain Relevance 0
Although both SHP-1 and SHP-2 are said to be positive regulators of signal transduction, their specific functions in platelets are not yet known.
Negative_regulation (regulators) of SHP-2 in platelets
7) Confidence 0.07 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.12 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox