INT267615

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.41
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
middle ear 2
eustachian tube 2
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 222 97.48 Very High Very High Very High
Inflammatory mediators 48 92.96 High High
Inflammatory response 22 87.56 High High
cytokine 129 72.36 Quite High
chemokine 34 5.00 Very Low Very Low Very Low
bradykinin 12 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Otitis Media 268 99.12 Very High Very High Very High
Breast Cancer 12 98.88 Very High Very High Very High
Stress 6 98.28 Very High Very High Very High
INFLAMMATION 288 97.48 Very High Very High Very High
Cholesteatoma 96 88.72 High High
Death 9 88.32 High High
Infection 28 84.52 Quite High
Otitis Media With Effusion 184 84.48 Quite High
Adhesions 28 82.24 Quite High
Hyperplasia 8 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines in response to stress, and enhances cell survival.
Positive_regulation (upregulated) of Localization (secreted) of glycoprotein associated with stress
1) Confidence 0.01 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2856549 Disease Relevance 0.63 Pain Relevance 0
These mediators have a role in the inflammatory processes of the middle ear such as vascular permeability changes, chemotaxis, stimulation of epithelial secretory activity, enhancement of mucous glycoprotein secretion, and production of other mediators.
Positive_regulation (enhancement) of Localization (secretion) of glycoprotein in middle ear associated with inflammation
2) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.79 Pain Relevance 0.42
PAF also stimulates secretion of mucus glycoprotein mediated by arachidonic acid metabolites, especially metabolites of the lipoxygenase pathway via a PAF-receptor dependent mechanism (244), and inhibits mucociliary clearance of the eustachian tube (245).
Positive_regulation (mediated) of Localization (secretion) of glycoprotein in eustachian tube
3) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.98 Pain Relevance 0.04

General Comments

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