INT267625

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.23
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klk1) extracellular space (KNG1) extracellular region (KNG1)
plasma membrane (KNG1) molecular_function (Klk1) cellular_component (Klk1)
KNG1 (Homo sapiens)
Klk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 26 100.00 Very High Very High Very High
Inflammation 113 77.76 Quite High
Pain 6 71.44 Quite High
b2 receptor 2 36.68 Quite Low
Inflammatory response 11 12.28 Low Low
cytokine 63 5.00 Very Low Very Low Very Low
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 100.00 Very High Very High Very High
Otitis Media With Effusion 92 99.04 Very High Very High Very High
Hereditary Angioedema 35 95.28 Very High Very High Very High
Stress 3 87.64 High High
Injury 5 85.52 High High
Systemic Lupus Erythematosus 1 85.52 High High
Increased Venous Pressure Under Development 6 84.32 Quite High
Edema 10 82.64 Quite High
INFLAMMATION 146 77.76 Quite High
Pain 5 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local bradykinin concentrations are much higher at the site of swelling than at unaffected sites26,32–36 One unusual family had a C1 inhibitor mutation with preserved kallikrein inhibitory function and presumably normal bradykinin.
bradykinin Binding (mutation) of kallikrein associated with pressure and volume under development and bradykinin
1) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 1.71 Pain Relevance 0.36
Kallikrein enzymatically cleaves HMWK to liberate bradykinin.
bradykinin Binding (liberate) of Kallikrein associated with bradykinin
2) Confidence 0.04 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.52 Pain Relevance 0.25

General Comments

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