INT267631

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
macrophage 2
IRF6 (Homo sapiens)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 22 93.48 High High
cytokine 126 93.24 High High
Inflammation 222 90.68 High High
Inflammatory mediators 48 48.32 Quite Low
chemokine 34 5.00 Very Low Very Low Very Low
bradykinin 12 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 288 93.12 High High
Otitis Media With Effusion 184 81.72 Quite High
Otitis Media 268 70.96 Quite High
Adhesions 28 68.72 Quite High
Hypercalcemia 6 59.52 Quite High
Infection 28 49.12 Quite Low
Hemophilus Infection 2 42.72 Quite Low
Blister 2 37.92 Quite Low
Influenza Virus Infection 2 28.56 Quite Low
Fibrosis 6 23.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these, IL-1 production is stimulated by LPS and leukotrienes (28, 32, 33).
LPS Positive_regulation (stimulated) of Gene_expression (production) of IL-1
1) Confidence 0.00 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.45 Pain Relevance 0.09
LPS is a potent stimulus for the production of macrophage-derived TNF and IL-1 (195).
LPS Positive_regulation (stimulus) of Gene_expression (production) of IL-1 in macrophage
2) Confidence 0.00 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.51 Pain Relevance 0.17

General Comments

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