INT267671

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.85
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Nexn) cytoplasm (Nexn)
Anatomy Link Frequency
cochlea 2
cleavage 1
Nexn (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 12 12.56 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 209 99.50 Very High Very High Very High
Diabetes Mellitus 52 95.68 Very High Very High Very High
Stress 10 92.60 High High
Pressure And Volume Under Development 8 87.88 High High
Death 32 87.00 High High
Albuminuria 27 84.92 Quite High
Deafness 40 76.16 Quite High
Renal Disease 39 74.24 Quite High
Sprains And Strains 4 73.44 Quite High
Injury 5 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degree of loss and apoptosis of OHC, especially with degraded F-actin, increased toward the base of the cochlea until 60% of the whole length and evenly distributed subsequently.
Protein_catabolism (degraded) of F-actin in cochlea associated with apoptosis
1) Confidence 0.85 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.82 Pain Relevance 0
We can summarize the observation of morphological changes of OHC as follows: 1) Noise exposure induced loss of OHC, and the number of lost OHC increased from the apex to the base, 2) There existed cells which were in the process of apoptosis among OHC which remained without loss and the number of such cells also increased toward the base, 3) Cells in the cochlea apex continued to have F-actin, while the rate of degradation of F-actin increased toward the base, 4) The characteristics of cellular damage according to 2) and 3) were evident around the region corresponding to 60% of the whole cochlea, and the degree of cellular damage around this area was similar to that distal to this region.
Protein_catabolism (degradation) of F-actin in cochlea associated with apoptosis
2) Confidence 0.56 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.54 Pain Relevance 0
The findings, such as chromatin condensation and hyper-staining, represent the process of apoptosis of OHC, and in this study we observed degradation of F-actin simultaneously during apoptosis so that we could find more information about the mechanism of cellular apoptosis.
Protein_catabolism (degradation) of F-actin associated with apoptosis
3) Confidence 0.56 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.54 Pain Relevance 0
FITC (-) was breakdown of F-actin; stereocilia was not stained with FITC or had abnormal morphology.
Protein_catabolism (breakdown) of F-actin
4) Confidence 0.56 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671795 Disease Relevance 0.43 Pain Relevance 0
In cultured podocytes, curcumin induced the phosphorylation of p38MAPK and downstream HSP25, inhibited COX-2 and the activation of caspase-3, and demonstrated a tendency to attenuate F-actin cleavage to G-actin monomers.
Protein_catabolism (cleavage) of F-actin in cleavage
5) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.81 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox