INT267678

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.34
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
frontal cortex 6
hippocampus 2
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 36 100.00 Very High Very High Very High
gABA 48 99.84 Very High Very High Very High
Hippocampus 20 96.96 Very High Very High Very High
Calcium channel 12 74.16 Quite High
carbamazepine 32 64.60 Quite High
Lamotrigine 16 63.84 Quite High
sodium channel 16 60.76 Quite High
repetitive firing 4 58.96 Quite High
Spinal cord 4 56.04 Quite High
Neurotransmitter 8 34.96 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 96.32 Very High Very High Very High
Epilepsy 124 81.84 Quite High
Convulsion 292 80.08 Quite High
Absence Epilepsy 36 77.60 Quite High
Partial Seizures 140 49.08 Quite Low
Dentatorubro-pallidoluysian Atrophy 76 5.00 Very Low Very Low Very Low
Infantile Spasms 72 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Juvenile Myoclonic Epilepsy 32 5.00 Very Low Very Low Very Low
Syndrome 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of Positive_regulation (regulation) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
1) Confidence 0.07 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (up) of Positive_regulation (regulation) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
2) Confidence 0.07 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (-) of in hippocampus Positive_regulation (regulation) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
3) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Positive_regulation (up) of in hippocampus Positive_regulation (regulation) of EAAC-1 in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
4) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.91

General Comments

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