INT267684

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 6.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS) intracellular (ARID1B) DNA binding (ARID1B)
carbohydrate metabolic process (INS) cell-cell signaling (INS) extracellular space (INS)
Anatomy Link Frequency
Heart 1
INS (Homo sapiens)
ARID1B (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 4 97.44 Very High Very High Very High
Inflammation 8 73.44 Quite High
antagonist 3 34.16 Quite Low
Etanercept 1 33.36 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
Serotonin 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obstructive Sleep Apnea 163 100.00 Very High Very High Very High
Apnoea 152 100.00 Very High Very High Very High
Insulin Resistance 18 100.00 Very High Very High Very High
Impaired Glucose Tolerance 7 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

4 99.36 Very High Very High Very High
Obesity 45 98.92 Very High Very High Very High
Metabolic Syndrome 74 98.60 Very High Very High Very High
Diabetes Mellitus 32 98.56 Very High Very High Very High
Pressure And Volume Under Development 5 95.56 Very High Very High Very High
Cv Unclassified Under Development 15 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The correlation between OSA and MS is complex and incompletely understood.18,19 Indeed, the independent association between OSA, insulin resistance, and the development of type 2 diabetes has been established in numerous works.3,5,6,9,20–22 Thus, OSA has been proposed as an extra component of MS, with intermittent hypoxia being identified as a potential triggering factor.3,20 However, the evidence for the contribution of OSA to the development of MS is far from conclusive.
insulin Binding (association) of OSA associated with apnoea, hypoxia, diabetes mellitus, metabolic syndrome and insulin resistance
1) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 2.39 Pain Relevance 0.04
Epidemiologic data from the Sleep Heart Health Study [1] suggested that OSA is associated with glucose intolerance and insulin resistance independent of obesity, and may lead to type 2 diabetes mellitus.
insulin Binding (associated) of OSA in Heart associated with apnoea, diabetes mellitus, obesity, insulin resistance and impaired glucose tolerance
2) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.68 Pain Relevance 0
OSA appears independently associated with insulin resistance and dyslipidemia (Ip et al 2002; Coughlin et al 2004; Pujabi et al 2004) even after correction for obesity.
insulin Binding (associated) of OSA associated with metabolic syndrome, obstructive sleep apnea and insulin resistance
3) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.64 Pain Relevance 0.05

General Comments

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