INT267698

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 20.47
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ARID1B) nucleus (ARID1B) intracellular (ARID1B)
DNA binding (ARID1B)
Anatomy Link Frequency
respiratory 1
ARID1B (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 19 99.24 Very High Very High Very High
Pain 3 94.64 High High
Serotonin 28 93.48 High High
Inflammation 31 93.16 High High
cytokine 18 59.80 Quite High
antagonist 12 40.64 Quite Low
Etanercept 4 39.84 Quite Low
Inflammatory response 3 30.32 Quite Low
depression 11 9.04 Low Low
alcohol 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apnoea 757 100.00 Very High Very High Very High
Obstructive Sleep Apnea 652 100.00 Very High Very High Very High
Metabolic Syndrome 426 100.00 Very High Very High Very High
Insulin Resistance 63 100.00 Very High Very High Very High
Cv Unclassified Under Development 60 100.00 Very High Very High Very High
Impaired Glucose Tolerance 25 99.92 Very High Very High Very High
Obesity 183 99.62 Very High Very High Very High
Diabetes Mellitus 136 99.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

20 98.64 Very High Very High Very High
Sleep Disorders 265 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further work is now needed to shed more light on the pathophysiology of this bidirectional association, as well as to ascertain whether glucose and/or other components of MS can be meaningfully used for appropriate referral and early detection of OSA in such patients.



Gene_expression (detection) of OSA associated with apnoea and metabolic syndrome
1) Confidence 0.63 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.06 Pain Relevance 0
Finally, we did not quantify insulin resistance (eg, by the Homeostatic Model Assessment), but we aimed to evaluate the utility of very simple metabolic parameters as used in everyday practice for the detection of OSA.
Gene_expression (detection) of OSA associated with apnoea and insulin resistance
2) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.27 Pain Relevance 0
Looking separately at each component of the metabolic syndrome, the presence of OSA was associated with serum glucose levels above the cut-off set by NCEP ATP III (?
Gene_expression (presence) of OSA associated with apnoea and metabolic syndrome
3) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.26 Pain Relevance 0
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep, ultimately leading to increased respiratory effort, oxyhemoglobin desaturation, sleep fragmentation, and excessive daytime sleepiness.1,2 Several studies have investigated the association of OSA with cardiovascular morbidity and mortality, systemic inflammation and impaired glucose metabolism.2–12
Gene_expression (desaturation) of OSA in respiratory associated with apnoea, inflammation and sleep disorders
4) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.22 Pain Relevance 0.05
The correlation between OSA and MS is complex and incompletely understood.18,19 Indeed, the independent association between OSA, insulin resistance, and the development of type 2 diabetes has been established in numerous works.3,5,6,9,20–22 Thus, OSA has been proposed as an extra component of MS, with intermittent hypoxia being identified as a potential triggering factor.3,20 However, the evidence for the contribution of OSA to the development of MS is far from conclusive.
Gene_expression (resistance) of OSA associated with apnoea, hypoxia, diabetes mellitus, metabolic syndrome and insulin resistance
5) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 2.38 Pain Relevance 0.04
Predictors of obstructive sleep apnea in males with metabolic syndrome

The aim of the present study was to examine the prevalence of metabolic syndrome (MS) and its components among obstructive sleep apnea (OSA) patients vs controls, as well as to investigate which of these components are strongly associated with the presence of OSA in subjects reporting symptoms indicating sleep-disordered breathing.

Gene_expression (presence) of OSA associated with apnoea and metabolic syndrome
6) Confidence 0.54 Published 2010 Journal Vascular Health and Risk Management Section Title Doc Link PMC2868349 Disease Relevance 1.77 Pain Relevance 0
For example, the faster overall decay of the REM bout distributions with OSA was attributed to faster time constants (particularly of the fast exponential) as well as an increase of the relative contribution of the fast component (at the expense of the slow component).
Gene_expression (decay) of OSA associated with apnoea
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.38 Pain Relevance 0
Although small differences are evident, the change in proportion of M:F in the OSA groups does not account for the observed differences reported in the main text.
Gene_expression (groups) of OSA associated with apnoea
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.35 Pain Relevance 0
Although most of the published bout duration analysis has focused on the presence or absence of OSA, recent data suggests that sleep stage stability may be associated with daytime symptoms in populations with syndromes of fatigue or pain[16], [17].
Neg (absence) Gene_expression (absence) of OSA associated with pain, apnoea, syndrome and fatigue
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.54 Pain Relevance 0.09
There is increasing evidence supporting a causal relationship between OSA and metabolic syndrome, including hypertension, insulin resistance, impaired glucose tolerance, and dyslipidemia, which are significant cardiac risk factors.
Gene_expression (resistance) of OSA associated with cv unclassified under development, tolerance, metabolic syndrome, obstructive sleep apnea, insulin resistance and impaired glucose tolerance
10) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.60 Pain Relevance 0.05
A 1997 systematic review of the health consequences of OSA and effectiveness of CPAP concluded that the pubic health risk of OSA was exaggerated and was highly critical of the paucity of high quality evidence supporting this therapy (Wright et al 1997).
Gene_expression (effectiveness) of OSA associated with obstructive sleep apnea
11) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.26 Pain Relevance 0
Significance of OSA
Gene_expression (Significance) of OSA associated with obstructive sleep apnea
12) Confidence 0.26 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.75 Pain Relevance 0.13
The presence of OSA has also been reported as an independent factor associated with increased mortality following first ever stroke or transient ischaemic attack (Parra et al 2004).
Gene_expression (presence) of OSA associated with cv general 4 under development, stroke and obstructive sleep apnea
13) Confidence 0.23 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.77 Pain Relevance 0
If OSA is not present at baseline, then patients should be followed with nocturnal oximetry as follows:
Neg (not) Gene_expression (present) of OSA associated with apnoea
14) Confidence 0.21 Published 2009 Journal Sleep Breath Section Body Doc Link PMC2824842 Disease Relevance 1.10 Pain Relevance 0
This finding supports the major role that IL-6 plays in obesity and extends it to pathophysiological processes linking obesity to IGM via leptin resistance and OSA.
Gene_expression (resistance) of OSA associated with apnoea and obesity
15) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.50 Pain Relevance 0.11
Other measures of OSA severity, including ODI, MinSaO2, ?
Gene_expression (severity) of OSA associated with apnoea
16) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.30 Pain Relevance 0
Third, there were no linear associations between OSA severity and HOMA estimates in the subjects with IGM compared to individually matched controls with NGM.
Gene_expression (severity) of OSA associated with apnoea
17) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.38 Pain Relevance 0
OSA is assessed using the three OSA items from the Child Sleep Habit's Questionnaire (CSHQ) [30].
Gene_expression (assessed) of OSA associated with apnoea
18) Confidence 0.04 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC3022790 Disease Relevance 1.14 Pain Relevance 0

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