INT2677

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Context Info
Confidence 0.44
First Reported 1979
Last Reported 1991
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.50
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Trim13) endoplasmic reticulum (Trim13) intracellular (Trim13)
ligase activity (Trim13) cytoplasm (Trim13) signal transducer activity (Trim13)
Anatomy Link Frequency
Mouse 1
longitudinal muscle 1
Trim13 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Somatostatin 1 99.16 Very High Very High Very High
analgesia 8 98.44 Very High Very High Very High
Analgesic 2 94.48 High High
narcan 2 91.68 High High
Immobilon 2 91.60 High High
opiate 7 82.40 Quite High
Disease Link Frequency Relevance Heat
Glioma 2 98.70 Very High Very High Very High
Neuroblastoma 2 98.44 Very High Very High Very High
Bordatella Infection 2 78.88 Quite High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mouse neuroblastoma x rat glioma hybrid cells (N x G, 108CC15) were used to study the inhibitory effects of the synthetic opioid D-Ala2-D-Leu5-enkephalin (DADLE), somatostatin, adrenaline-alpha 2 and angiotensin II on voltage-dependent Ca(2+)-currents (ICa) using the patch-clamp technique in the whole-cell configuration mode.
Regulation (effects) of Leu5 in Mouse associated with neuroblastoma, somatostatin, enkephalin, opioid and glioma
1) Confidence 0.44 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1656335 Disease Relevance 0.50 Pain Relevance 0.28
In the present study, we examined the effect of dynorphin on morphine-, beta-endorphin-, D-ala2-D-leu5-enkephalin- or Sandoz FK33824-induced analgesia in both naive, morphine-tolerant and morphine-dependent mice.
Spec (examined) Regulation (effect) of leu5 associated with dynorphin, enkephalin, analgesia and morphine
2) Confidence 0.44 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6116798 Disease Relevance 0 Pain Relevance 2.00
A further comparison of arylsulfatase effects on morphine and on D-Ala-2-D-Leu5-enkephalin indicated that the morphine effect, unlike the D-Ala-2-D-Leu5-enkephalin effect, could not be reversed by washing and that morphine, unlike D-Ala2-D-Leu5-enkephalin, became much less sensitive to naloxone antagonism.
Regulation (effects) of Leu5 associated with narcan, enkephalin and morphine
3) Confidence 0.44 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6310079 Disease Relevance 0 Pain Relevance 1.16
The effect of various analogues of met5- and leu5-enkephalin were determined on the reduction in twitch height of the electrically-stimulated longitudinal muscle preparation of the guinea-pig ileum and of the isolated mouse vas deferens. 2.
Regulation (effect) of leu5-enkephalin in longitudinal muscle associated with enkephalin
4) Confidence 0.11 Published 1979 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 498593 Disease Relevance 0 Pain Relevance 0.47

General Comments

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