INT267703

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.85
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ARID1B) nucleus (ARID1B) intracellular (ARID1B)
DNA binding (ARID1B)
Anatomy Link Frequency
upper 1
ARID1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 3 96.64 Very High Very High Very High
Clonidine 3 94.20 High High
addiction 3 91.92 High High
Serotonin 21 90.64 High High
cytokine 18 58.80 Quite High
antagonist 9 55.44 Quite High
alcohol 21 54.32 Quite High
sSRI 6 35.76 Quite Low
Inflammation 18 9.68 Low Low
tolerance 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obstructive Sleep Apnea 489 100.00 Very High Very High Very High
Apnoea 387 100.00 Very High Very High Very High
Obesity 99 100.00 Very High Very High Very High
Diabetes Mellitus 60 99.00 Very High Very High Very High
Weight Loss 18 98.32 Very High Very High Very High
INFLAMMATION 24 96.64 Very High Very High Very High
Prediabetic State 54 95.36 Very High Very High Very High
Insulin Resistance 48 88.20 High High
Sleep Disorders 156 86.56 High High
Malocclusion 3 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The weighted time constants of the REM sleep multi-exponential decays were 12.8, 8.6, and 4.5 epochs for control, mild OSA, and severe OSA, respectively (single exponential fits: 14.6, 10.8, 4.8 epochs, respectively).
Regulation (control) of OSA associated with apnoea
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.53 Pain Relevance 0
The weighted time constants of the REM sleep multi-exponential decays were 12.8, 8.6, and 4.5 epochs for control, mild OSA, and severe OSA, respectively (single exponential fits: 14.6, 10.8, 4.8 epochs, respectively).
Regulation (control) of OSA associated with apnoea
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.48 Pain Relevance 0
The changes in bout distribution dynamics was not accounted for by a change in the representation of males versus females in the control versus OSA groups (Supplemental Material, Table S1).
Regulation (change) of OSA associated with apnoea
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.40 Pain Relevance 0
In theory, the emerging knowledge on the neurochemistry of upper airway dilator muscle control would support a role for pharmacotherapy in the management of OSA.
Regulation (role) of OSA in upper associated with obstructive sleep apnea
4) Confidence 0.17 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.47 Pain Relevance 0.27
MAS therapy can be an effective treatment for OSA but it has lower efficacy in improving polysomnographic variables and has lower response rates than CPAP.
Regulation (effective) of OSA associated with obstructive sleep apnea
5) Confidence 0.17 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.58 Pain Relevance 0.05
Dixon et al investigated the effect of laparoscopic gastric banding on severely obese subjects with severe OSA (Dixon et al 2005).
Spec (investigated) Regulation (effect) of OSA associated with obesity and obstructive sleep apnea
6) Confidence 0.17 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.27 Pain Relevance 0.05
Third, we identified two distinct biomarker profiles associated with OSA in subjects with NGM and IGM that may reflect pathophysiology of glucose dysregulation in OSA and severe obesity.
Regulation (dysregulation) of OSA associated with apnoea and obesity
7) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.10 Pain Relevance 0
Notwithstanding previous studies supporting independent associations between obstructive sleep apnea (OSA) and prevalence of diabetes, the underlying pathogenesis of impaired glucose regulation in OSA remains unclear.
Regulation (regulation) of OSA associated with apnoea and diabetes mellitus
8) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3002325 Disease Relevance 0.99 Pain Relevance 0.03
and IL-6 have been discerned in our study, which can illuminate potential mechanisms for glucose dysregulation in OSA.
Regulation (dysregulation) of OSA associated with apnoea
9) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.03 Pain Relevance 0.05

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