INT267746

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.25
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mvp) cytoplasm (Mvp)
Anatomy Link Frequency
nasal 1
Mvp (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 24 90.16 High High
cytokine 102 47.04 Quite Low
Inflammatory response 6 23.20 Low Low
Inflammation 60 18.28 Low Low
chemokine 36 7.72 Low Low
Pain 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Immobilon 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mitral Valve Prolapse 216 100.00 Very High Very High Very High
Immunization 132 82.88 Quite High
Infection 222 80.04 Quite High
Autoimmune Disease 6 70.84 Quite High
Chlamydia Infection 42 52.80 Quite High
Influenza Virus Infection 6 44.28 Quite Low
Reprotox - General 3 6 42.64 Quite Low
INFLAMMATION 66 23.20 Low Low
Weight Loss 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, immune sera from mice immunized with GL-vaults did not produce IgG against MVP (Fig. 6d), demonstrating that repeated i.n. administration of vaults does not induce anti-vault antibody production when designed with the z peptide to enhance development of immune responses.
Neg (not) Gene_expression (produce) of MVP associated with mitral valve prolapse
1) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.79 Pain Relevance 0.08
Expression of MVP in insect cells using the baculovirus system results in production of vault-like particles formed entirely from the expressed MVP, leading to the conclusion that MVP alone is sufficient to form vault-like particles.
Gene_expression (expressed) of MVP associated with mitral valve prolapse
2) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.60 Pain Relevance 0
Expression of MVP in insect cells using the baculovirus system results in production of vault-like particles formed entirely from the expressed MVP, leading to the conclusion that MVP alone is sufficient to form vault-like particles.
Gene_expression (Expression) of MVP associated with mitral valve prolapse
3) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.52 Pain Relevance 0
We tested the ability of vaults expressing (cp-MVP-z) or lacking (cp-MVP) the Fc binding peptide to adhere to mouse Ig isotypes which are generally found in nasal secretions (IgG and IgA) using an ELISA assay.
Gene_expression (expressing) of cp-MVP in nasal associated with mitral valve prolapse
4) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.90 Pain Relevance 0
However, MOMP-vault exposure induced significantly greater levels of IL-1?
Gene_expression (exposure) of MOMP-vault
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.51 Pain Relevance 0.07
Sera from these mice also did not produce antibody to cp-MVP vaults by Western blot analysis (data not shown).
Neg (not) Gene_expression (produce) of cp-MVP associated with mitral valve prolapse
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.93 Pain Relevance 0.07

General Comments

This test has worked.

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