INT267750

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.53
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 199 100.00 Very High Very High Very High
cytokine 57 98.36 Very High Very High Very High
reflex sympathetic dystrophy 3 88.04 High High
antagonist 3 73.00 Quite High
Antinociceptive 2 71.12 Quite High
IPN 6 67.12 Quite High
Inflammatory response 13 47.48 Quite Low
chemokine 20 28.08 Quite Low
Neuropathic pain 2 17.00 Low Low
Arthritis 10 15.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 214 100.00 Very High Very High Very High
Apoptosis 3 94.24 High High
Bone Fracture 3 89.48 High High
Complex Regional Pain Syndromes 3 88.04 High High
Targeted Disruption 12 74.00 Quite High
Inflammatory Pain 6 67.12 Quite High
Crystal Associated Disease 150 54.16 Quite High
Immunization 22 32.20 Quite Low
Peritonitis 14 25.40 Quite Low
Neuropathic Pain 2 17.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The participation of caspase-1 in this inflammatory symptom was not associated with the production of pro-inflammatory cytokines (TNF?
caspase-1 Binding (associated) of associated with inflammation and cytokine
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.03 Pain Relevance 0.66
The ASC adapter contains a PYD domain that mediates interaction with a homologous domain on NLRP, as well as a CARD domain that interacts with caspase-1.
caspase-1 Binding (interacts) of
2) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.21 Pain Relevance 0.16
For the NLRP3 inflammasome, a second adapter - the Cardinal protein - is needed to recruit a second molecule of caspase-1, so as to form a dimer with the caspase-1 recruited by ASC (Figure 1).
caspase-1 Binding (recruit) of
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.20 Pain Relevance 0.10
Two caspase-1 molecules are then recruited and activated by the complex which then leads to the activation of caspase-1 and subsequent IL-1?
caspase-1 Binding (complex) of
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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